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Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 1 (BLOC1S1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS719940

MBS719940 is an antibody targeting BLOC1S1. Also known as Rabbit anti-human Biogenesis of lysosome-related organelles complex 1 subunit 1 polyclonal Antibody. Reactive in Human. Host: Rabbit. More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Biogenesis of lysosome-related organelles complex 1 subunit 1 polyclonal Antibody
Product Gene Name
anti-BLOC1S1 antibody
Product Synonym Names
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) (GCN5-like protein 1) (Protein RT14), BLOC1S1, BLOS1, GCN5L1, RT14
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Upon receipt store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: Biogenesis of lysosome-related organelles complex 1 subunit 1 (MBS719940)
Biotin Conjugated Antibody: Biogenesis of lysosome-related organelles complex 1 subunit 1 (MBS719650)
Matching Pairs
Unconjugated Antibody: Biogenesis of lysosome-related organelles complex 1 subunit 1 (MBS719940)
HRP Conjugated Antibody: Biogenesis of lysosome-related organelles complex 1 subunit 1 (MBS719653)
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OMIM
601444
3D Structure
ModBase 3D Structure for P78537
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1 protein (1-153AA)
Immunogen Species
Homo sapiens (Human)
Research Area
Cardiovascular
Target Names
BLOC1S1
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-167208
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-BLOC1S1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-BLOC1S1 antibody
WB:1:500-1:5000
IHC:1:20-1:200
IF:1:50-1:200

Western Blot (WB) of anti-BLOC1S1 antibody

Western blot
All lanes: Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody at 2ug/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 18,15 kDa
Observed band size: 75 kDa
Rabbit Anti-BLOC1S1 Polyclonal Antibody – Cat# MBS719940

Immunofluorescence (IF) of anti-BLOC1S1 antibody

Immunofluorescent analysis of HepG2 cells using MBS719940 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Rabbit Anti-BLOC1S1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS719940

Immunohistochemistry (IHC) of anti-BLOC1S1 antibody

Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS719940 at dilution of 1:100
Rabbit Anti-BLOC1S1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS719940

Immunohistochemistry (IHC) of anti-BLOC1S1 antibody

Immunohistochemistry of paraffin-embedded human testis tissue using MBS719940 at dilution of 1:100
Rabbit Anti-BLOC1S1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS719940

Other Notes

Small volumes of anti-BLOC1S1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BLOC1S1. It may not necessarily be applicable to this product.

NCBI GI #
315113895
NCBI GeneID
2647
NCBI Accession #
NP_001478.2
UniProt Primary Accession #
P78537
UniProt Secondary Accession #
Q6NZ45; A1L4Q9
UniProt Related Accession #
P78537
GenBank Nucleotide #
NM_001487.3
NCBI Official Full Name
biogenesis of lysosome-related organelles complex 1 subunit 1
NCBI Official Synonym Full Names
biogenesis of lysosomal organelles complex 1 subunit 1
NCBI Official Symbol
BLOC1S1
NCBI Official Synonym Symbols
RT14; BLOS1; MICoA; GCN5L1
UniProt Protein Name
Biogenesis of lysosome-related organelles complex 1 subunit 1
UniProt Synonym Protein Names
GCN5-like protein 1; Protein RT14
Protein Family
Biogenesis of lysosome-related organelles complex
UniProt Gene Name
BLOC1S1
UniProt Synonym Gene Names
BLOS1; GCN5L1; RT14; BLOC-1 subunit 1
UniProt Entry Name
BL1S1_HUMAN
NCBI Protein Information
biogenesis of lysosome-related organelles complex 1 subunit 1

NCBI Summary for BLOC1S1

BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM, Mar 2008]
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UniProt Comments for BLOC1S1

BLOC1S1: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system. Belongs to the BLOC1S1 family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Nuclear receptor co-regulator; Vesicle

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: cytosol; extracellular space; lysosomal membrane; mitochondrial intermembrane space; mitochondrial matrix

Molecular Function: protein binding

Biological Process: aerobic respiration; anterograde axon cargo transport; anterograde synaptic vesicle transport; endosome transport; melanosome organization and biogenesis; neurite development; peptidyl-lysine acetylation; platelet dense granule organization and biogenesis; post-Golgi vesicle-mediated transport
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Research Articles on BLOC1S1

1. The mitochondrial acetylation status controlled by Sirt3 and its proposed opponent GCN5L1 is an important regulator of the metabolic adaptation of mitochondrial translation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BLOC1S1 antibody

 Reference Product  PubMed Publications
 DTNBP1 antibody  >10 publications with BLOC1S1 and DTNBP1
 BLOC1S3 antibody  >7 publications with BLOC1S1 and BLOC1S3
 BLOC1S2 antibody  >6 publications with BLOC1S1 and BLOC1S2
 SNAPIN antibody  >3 publications with BLOC1S1 and SNAPIN

Pathways associated with anti-BLOC1S1 antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-BLOC1S1 antibody

 Disease Name  Pubmed Publications
 Eye Diseases Antibodies  >10 publications with BLOC1S1 and Eye Diseases
 Cognition Disorders Antibodies  >1 publications with BLOC1S1 and Cognition Disorders
 Inflammation Antibodies  >1 publications with BLOC1S1 and Inflammation

Organs/Tissues associated with anti-BLOC1S1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with BLOC1S1 and Brain
 Uncharacterized Tissue Antibodies  >4 publications with BLOC1S1 and Uncharacterized Tissue
 Eye Antibodies  >3 publications with BLOC1S1 and Eye
 Embryonic Tissue Antibodies  >2 publications with BLOC1S1 and Embryonic Tissue
 Skin Antibodies  >2 publications with BLOC1S1 and Skin
 Intestine Antibodies  >1 publications with BLOC1S1 and Intestine
 Liver Antibodies  >1 publications with BLOC1S1 and Liver
 Muscle Antibodies  >1 publications with BLOC1S1 and Muscle
 Heart Antibodies  >1 publications with BLOC1S1 and Heart
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