Endoribonuclease Dicer (DICER1) ELISA Kit for Human

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.

Protein type: RNA processing; Cell development/differentiation; EC 3.1.26.3; Helicase; Ribonuclease; RNA-binding

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: axon; cytoplasm; cytosol; dendrite; ER-Golgi intermediate compartment; growth cone; nucleus

Molecular Function: ATP binding; deoxyribonuclease I activity; DNA binding; double-stranded RNA binding; endoribonuclease activity; helicase activity; metal ion binding; miRNA binding; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding

Biological Process: angiogenesis; branching morphogenesis of a tube; cardiac muscle cell development; cartilage development; cerebral cortex development; defense response to virus; DNA fragmentation during apoptosis; embryonic hindlimb morphogenesis; gene expression; hair follicle morphogenesis; inner ear receptor cell development; lung development; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; mRNA stabilization; multicellular organism growth; myelin formation in the peripheral nervous system; myoblast cell differentiation involved in skeletal muscle regeneration; negative regulation of transcription from RNA polymerase II promoter; nerve development; neurite morphogenesis; olfactory bulb interneuron differentiation; positive regulation of myelination; positive regulation of Schwann cell differentiation; post-embryonic development; pre-microRNA processing; regulation of cell cycle; regulation of neuron differentiation; regulation of oligodendrocyte differentiation; regulation of viral genome replication; reproductive structure development; RNA interference, conversion of ds siRNA to ss siRNA; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA interference, targeting of mRNA for destruction; RNA-mediated gene silencing; spinal cord motor neuron differentiation; spindle assembly; spleen development; stem cell maintenance; zygote asymmetric cell division

Disease: Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2