Neurokinin B (NKB) ELISA Kit for Human

Name: Human NKB ELISA Kit; Neurokinin B; MyBioSource
Brand: MyBioSource
SKU: MBS760185
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS760185

Principle of the Assay: This kit was based on Competitive-ELISA detection method. The microtiter plate provided in this kit has been pre-coated with target. During the reaction, target in the sample or standard competes with a fixed amount of target on the… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Neurokinin B (NKB), ELISA Kit

Full Product Name

Human Neurokinin B ELISA Kit

Product Gene Name

NKB elisa kit

Product Synonym Names

NKB

Species Reactivity

Human

Assay Type

Competitive

Samples

Serum, plasma, tissue homogenates and other biological fluids

Detection Range

15.625-1000pg/ml

Sensitivity

9.375pg/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of NKB. No significant cross-reactivity or interference between NKB and analogues was observed.

Preparation and Storage

Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C

Inter-assay Precision

CV<10%

Intra-assay Precision

CV<8%

Molecular Weight

11,358 Da

OMIM

162330

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of NKB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKB purchase

MBS760185 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neurokinin B (NKB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NKB. The ELISA analytical biochemical technique of the MBS760185 kit is based on NKB antibody-NKB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NKB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NKB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for NKB. It may not necessarily be applicable to this product.

NCBI GI #

8572053

NCBI GeneID

6866

NCBI Accession #

AAF76980.1

UniProt Secondary Accession #

Q6IAG2; Q71BC6; Q71BC9

UniProt Related Accession #

Q9UHF0

NCBI Official Full Name

neurokinin B

NCBI Official Synonym Full Names

tachykinin 3

NCBI Official Symbol

TAC3

NCBI Official Synonym Symbols

NKB; HH10; NKNB; PRO1155; ZNEUROK1

UniProt Protein Name

Tachykinin-3

UniProt Synonym Protein Names

ZNEUROK1

Protein Family

Neurokinin

UniProt Gene Name

TAC3

UniProt Synonym Gene Names

NKNB; NKB

UniProt Entry Name

TKNK_HUMAN

NCBI Protein Information

tachykinin-3

NCBI Summary for NKB

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

UniProt Comments for NKB

TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: protein binding; receptor binding

Biological Process: female pregnancy; neuropeptide signaling pathway; tachykinin signaling pathway

Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia

Research Articles on NKB

1. Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NKB elisa kit

Reference Product	PubMed Publications
TACR3 elisa kit	>44 publications with NKB and TACR3
PROKR2 elisa kit	>22 publications with NKB and PROKR2
KISS1R elisa kit	>21 publications with NKB and KISS1R
PROK2 elisa kit	>19 publications with NKB and PROK2
GNRH1 elisa kit	>15 publications with NKB and GNRH1
TAC1 elisa kit	>8 publications with NKB and TAC1
TACR1 elisa kit	>3 publications with NKB and TACR1
TACR2 elisa kit	>2 publications with NKB and TACR2

Pathways associated with NKB elisa kit

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram
Tachykinin Receptors Bind Tachykinins Pathway antibodies	Tachykinin Receptors Bind Tachykinins Pathway Diagram

Diseases associated with NKB elisa kit

Disease Name	Pubmed Publications
Hypogonadism Antibodies	>37 publications with NKB and Hypogonadism
Congenital Abnormalities Antibodies	>12 publications with NKB and Congenital Abnormalities
Idiopathic Hypogonadotropic Hypogonadism Antibodies	>12 publications with NKB and Idiopathic Hypogonadotropic Hypogonadism
Nervous System Diseases Antibodies	>6 publications with NKB and Nervous System Diseases
Neoplasm Metastasis Antibodies	>2 publications with NKB and Neoplasm Metastasis
Gastrointestinal Diseases Antibodies	>2 publications with NKB and Gastrointestinal Diseases
Fetal Growth Retardation Antibodies	>1 publications with NKB and Fetal Growth Retardation
Abnormalities, Multiple Antibodies	>1 publications with NKB and Abnormalities, Multiple
Spinal Cord Diseases Antibodies	>1 publications with NKB and Spinal Cord Diseases
Neurobehavioral Manifestations Antibodies	>1 publications with NKB and Neurobehavioral Manifestations

Organs/Tissues associated with NKB elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>15 publications with NKB and Brain
Placenta Antibodies	>3 publications with NKB and Placenta
Uterus Antibodies	>1 publications with NKB and Uterus
Connective Tissue Antibodies	>1 publications with NKB and Connective Tissue
Embryonic Tissue Antibodies	>1 publications with NKB and Embryonic Tissue