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Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS761785

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human NOTCH2 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human NOTCH2 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neurogenic locus notch homolog protein 2 (NOTCH2), ELISA Kit
Full Product Name
Human Neurogenic locus notch homolog protein 2 ELISA Kit
Product Gene Name
NOTCH2 elisa kit
Product Synonym Names
NOTCH2/AGS2/hN2/Notch (Drosophila) homolog 2/notch 2Notch homolog 2 (Drosophila)/Notch homolog 2
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
265,370 Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of NOTCH2 elisa kit

Human NOTCH2 ELISA Kit – Cat# MBS761785

Typical Standard Curve of NOTCH2 elisa kit

Human NOTCH2 ELISA Kit, Typical Standard Curve – Cat# MBS761785

Other Notes

Small volumes of NOTCH2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NOTCH2 purchase

MBS761785 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neurogenic locus notch homolog protein 2 (NOTCH2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NOTCH2. The ELISA analytical biochemical technique of the MBS761785 kit is based on NOTCH2 antibody-NOTCH2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NOTCH2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NOTCH2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for NOTCH2. It may not necessarily be applicable to this product.

NCBI GI #
767172165
NCBI GeneID
29492
NCBI Accession #
NP_077334.2
UniProt Related Accession #
Q9QW30
GenBank Nucleotide #
NM_024358.2
NCBI Official Full Name
neurogenic locus notch homolog protein 2
NCBI Official Synonym Full Names
notch 2
NCBI Official Symbol
Notch2
UniProt Protein Name
Neurogenic locus notch homolog protein 2
Protein Family
Neurogenic locus notch homolog protein
UniProt Gene Name
Notch2
UniProt Synonym Gene Names
Notch 2
UniProt Entry Name
NOTC2_RAT
NCBI Protein Information
neurogenic locus notch homolog protein 2

NCBI Summary for NOTCH2

transmembrane protein that may be involved in cellular interactions that specify cell fate [RGD, Feb 2006]

UniProt Comments for NOTCH2

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component: cell surface; cilium; cytosol; extracellular region; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex

Molecular Function: calcium ion binding; enzyme binding; NF-kappaB binding; receptor activity

Biological Process: bone remodeling; cell cycle arrest; cell fate determination; cell growth; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; liver development; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; myeloid dendritic cell differentiation; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; organ morphogenesis; placenta development; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; regulation of developmental process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; tissue regeneration; transcription, DNA-dependent; wound healing
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Research Articles on NOTCH2

1. An increase in expression of selective NOTCH receptors (NOTCH1 and -2), ligand (JAGGED2), and target genes (HES1, HEY1, and HEY2) was observed in NP cells following cytokine treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NOTCH2 elisa kit

 Reference Product  PubMed Publications
 Rbpj elisa kit  >32 publications with NOTCH2 and Rbpj
 Numb elisa kit  >10 publications with NOTCH2 and Numb
 Dtx1 elisa kit  >6 publications with NOTCH2 and Dtx1
 Numbl elisa kit  >3 publications with NOTCH2 and Numbl
 Psen2 elisa kit  >3 publications with NOTCH2 and Psen2
 Psen1 elisa kit  >3 publications with NOTCH2 and Psen1
 Rbpsuh elisa kit  >1 publications with NOTCH2 and Rbpsuh

Pathways associated with NOTCH2 elisa kit

 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
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