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Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762219

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human IRAK3 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human IRAK3 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-1 receptor-associated kinase 3 (IRAK3), ELISA Kit
Full Product Name
Human Interleukin-1 receptor-associated kinase 3 ELISA Kit
Product Gene Name
IRAK3 elisa kit
Product Synonym Names
IRAK3/IL-1 receptor-associated kinase M (IRAK-M)/ASRT5/IRAK-M/ASRT5/EC 2.7.11.1/IL-1 receptor-associated kinase M/interleukin-1 receptor-associated kinase 3/IRAK-3/IRAKM/IRAK-M
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
78.125-5000pg/ml
Sensitivity
46.875pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
60,608 Da
OMIM
604459
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of IRAK3 elisa kit

Human IRAK3 ELISA Kit – Cat# MBS762219

Typical Standard Curve of IRAK3 elisa kit

Human IRAK3 ELISA Kit, Typical Standard Curve – Cat# MBS762219

Other Notes

Small volumes of IRAK3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRAK3 purchase

MBS762219 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin-1 receptor-associated kinase 3 (IRAK3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IRAK3. The ELISA analytical biochemical technique of the MBS762219 kit is based on IRAK3 antibody-IRAK3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IRAK3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IRAK3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IRAK3. It may not necessarily be applicable to this product.

NCBI GI #
216547519
NCBI GeneID
11213
NCBI Accession #
NP_009130.2
UniProt Secondary Accession #
B4DQ57
UniProt Related Accession #
Q9Y616
GenBank Nucleotide #
NM_007199.2
NCBI Official Full Name
interleukin-1 receptor-associated kinase 3 isoform a
NCBI Official Synonym Full Names
interleukin 1 receptor associated kinase 3
NCBI Official Symbol
IRAK3
NCBI Official Synonym Symbols
ASRT5; IRAKM
UniProt Protein Name
Interleukin-1 receptor-associated kinase 3
UniProt Synonym Protein Names
IL-1 receptor-associated kinase M; IRAK-M
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
IRAK3
UniProt Synonym Gene Names
IRAK-3; IRAK-M
UniProt Entry Name
IRAK3_HUMAN
NCBI Protein Information
interleukin-1 receptor-associated kinase 3

NCBI Summary for IRAK3

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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UniProt Comments for IRAK3

IRAK3: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: EC 2.7.11.1; IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: cytoplasm; nucleus

Molecular Function: ATP binding; magnesium ion binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity

Biological Process: activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; inhibition of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of innate immune response; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein complex disassembly; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; regulation of protein complex disassembly; response to exogenous dsRNA; response to lipopolysaccharide; response to peptidoglycan; response to virus

Disease: Asthma-related Traits, Susceptibility To, 5
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Research Articles on IRAK3

1. IRAK3 methylation was associated with tumor stage and poor prognosis of hepatocellular carcinoma patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IRAK3 elisa kit

 Reference Product  PubMed Publications
 IRAK2 elisa kit  >127 publications with IRAK3 and IRAK2
 TNF elisa kit  >52 publications with IRAK3 and TNF
 MYD88 elisa kit  >26 publications with IRAK3 and MYD88
 TRAF6 elisa kit  >18 publications with IRAK3 and TRAF6
 IRAK4 elisa kit  >14 publications with IRAK3 and IRAK4
 TLR9 elisa kit  >7 publications with IRAK3 and TLR9
 TOLLIP elisa kit  >7 publications with IRAK3 and TOLLIP
 TIRAP elisa kit  >2 publications with IRAK3 and TIRAP
 IL1R1 elisa kit  >1 publications with IRAK3 and IL1R1

Pathways associated with IRAK3 elisa kit

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram

Diseases associated with IRAK3 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >61 publications with IRAK3 and Inflammation
 Necrosis Antibodies  >38 publications with IRAK3 and Necrosis
 Lung Diseases Antibodies  >19 publications with IRAK3 and Lung Diseases
 Disease Models, Animal Antibodies  >12 publications with IRAK3 and Disease Models, Animal
 Liver Diseases Antibodies  >6 publications with IRAK3 and Liver Diseases
 Heart Diseases Antibodies  >4 publications with IRAK3 and Heart Diseases
 Reperfusion Injury Antibodies  >3 publications with IRAK3 and Reperfusion Injury
 Kidney Diseases Antibodies  >2 publications with IRAK3 and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >2 publications with IRAK3 and Drug-Induced Liver Injury
 Lung Neoplasms Antibodies  >2 publications with IRAK3 and Lung Neoplasms

Organs/Tissues associated with IRAK3 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >59 publications with IRAK3 and Blood
 Lung Antibodies  >27 publications with IRAK3 and Lung
 Bone Antibodies  >14 publications with IRAK3 and Bone
 Bone Marrow Antibodies  >11 publications with IRAK3 and Bone Marrow
 Placenta Antibodies  >4 publications with IRAK3 and Placenta
 Brain Antibodies  >4 publications with IRAK3 and Brain
 Heart Antibodies  >4 publications with IRAK3 and Heart
 Kidney Antibodies  >4 publications with IRAK3 and Kidney
 Eye Antibodies  >3 publications with IRAK3 and Eye
 Uterus Antibodies  >2 publications with IRAK3 and Uterus
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