Inositol Monophosphatase 1 (IMPA1) ELISA Kit for Human

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

IMPA1: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.94; Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein); Motility/polarity/chemotaxis; EC 3.1.3.25

Chromosomal Location of Human Ortholog: 8q21.13-q21.3

Cellular Component: cytoplasm; cytosol

Molecular Function: identical protein binding; inositol-1(or 4)-monophosphatase activity; lithium ion binding; magnesium ion binding; manganese ion binding; protein binding; protein homodimerization activity

Biological Process: inositol biosynthetic process; inositol metabolic process; inositol phosphate dephosphorylation; inositol phosphate metabolic process; phosphate metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide phosphorylation; signal transduction