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Filamin-B (FLNB) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762944

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-FLNB antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-FLNB antibody was used as detection antibodies. The standards, test… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Filamin-B (FLNB), ELISA Kit
Full Product Name
Human Filamin-B ELISA Kit
Product Gene Name
FLNB elisa kit
Product Synonym Names
FLNB (Filamin-B)/FLN1L/FLN3/TABP/TAP/FLN-B/Fh1/Truncated ABP/Filamin-3/Filamin homolog 1/Beta-filamin/Actin-binding-like protein/Truncated actin-binding protein/Thyroid autoantigen/ABP-278/ABP-280 homolog
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
31.25-2000pg/ml
Sensitivity
18.75pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
276,939 Da
OMIM
108720
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of FLNB elisa kit

Human FLNB ELISA Kit – Cat# MBS762944

Typical Standard Curve of FLNB elisa kit

Human FLNB ELISA Kit, Typical Standard Curve – Cat# MBS762944

Other Notes

Small volumes of FLNB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FLNB purchase

MBS762944 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Filamin-B (FLNB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLNB. The ELISA analytical biochemical technique of the MBS762944 kit is based on FLNB antibody-FLNB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLNB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLNB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.

NCBI GI #
256222415
NCBI GeneID
2317
NCBI Accession #
NP_001157791.1
UniProt Secondary Accession #
Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4
UniProt Related Accession #
O75369
GenBank Nucleotide #
NM_001164319.1
NCBI Official Full Name
filamin-B isoform 4
NCBI Official Synonym Full Names
filamin B
NCBI Official Symbol
FLNB
NCBI Official Synonym Symbols
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280
UniProt Protein Name
Filamin-B
UniProt Synonym Protein Names
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
Protein Family
Filamin
UniProt Gene Name
FLNB
UniProt Synonym Gene Names
FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP
UniProt Entry Name
FLNB_HUMAN
NCBI Protein Information
filamin-B

NCBI Summary for FLNB

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
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UniProt Comments for FLNB

FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: actin cytoskeleton; brush border; cell cortex; cytoplasm; cytosol; focal adhesion; integral to membrane; plasma membrane; stress fiber; Z disc

Molecular Function: actin binding; identical protein binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; cytokine and chemokine mediated signaling pathway; cytoskeletal anchoring; signal transduction; skeletal muscle development

Disease: Atelosteogenesis, Type I; Atelosteogenesis, Type Iii; Boomerang Dysplasia; Larsen Syndrome; Spondylocarpotarsal Synostosis Syndrome
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Research Articles on FLNB

1. Polymorphism at rs11720285, rs11130605 and rs9809315, all of which are located either 5' of the transcription start site or in intron 1 of the FLNB gene has been identified as significantly associated with BMD in Caucasian women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FLNB elisa kit

 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram

Diseases associated with FLNB elisa kit

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >21 publications with FLNB and Congenital Abnormalities
 Spondylocarpotarsal synostosis Antibodies  >7 publications with FLNB and Spondylocarpotarsal synostosis
 Boomerang dysplasia Antibodies  >6 publications with FLNB and Boomerang dysplasia
 Nervous System Diseases Antibodies  >5 publications with FLNB and Nervous System Diseases
 Liver Diseases Antibodies  >3 publications with FLNB and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with FLNB and Liver Neoplasms
 Adenocarcinoma Antibodies  >3 publications with FLNB and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with FLNB and Carcinoma, Hepatocellular
 ATELOSTEOGENESIS, TYPE III Antibodies  >3 publications with FLNB and ATELOSTEOGENESIS, TYPE III
 Cardiovascular Diseases Antibodies  >2 publications with FLNB and Cardiovascular Diseases

Organs/Tissues associated with FLNB elisa kit

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >21 publications with FLNB and Bone
 Connective Tissue Antibodies  >7 publications with FLNB and Connective Tissue
 Heart Antibodies  >4 publications with FLNB and Heart
 Blood Antibodies  >4 publications with FLNB and Blood
 Vascular Antibodies  >4 publications with FLNB and Vascular
 Brain Antibodies  >4 publications with FLNB and Brain
 Muscle Antibodies  >3 publications with FLNB and Muscle
 Nerve Antibodies  >3 publications with FLNB and Nerve
 Liver Antibodies  >3 publications with FLNB and Liver
 Embryonic Tissue Antibodies  >2 publications with FLNB and Embryonic Tissue
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