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Interleukin-6 Receptor Subunit Beta (GP130/IL6ST) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763919

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human sgp130 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human sgp130 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-6 receptor subunit beta (Gp130/IL6ST), ELISA Kit
Full Product Name
Human Interleukin-6 receptor subunit beta ELISA Kit
Product Gene Name
Gp130/IL6ST elisa kit
Product Synonym Names
sgp130 (soluble Glucoprotein 130)//IL6ST/CD130/CDW130/IL-6RB/IR6RB/Interleukin 6 signal transducer
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.25-16ng/ml
Sensitivity
0.15ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
102,451 Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of Gp130/IL6ST elisa kit

Human GP130/IL6ST ELISA Kit – Cat# MBS763919

Typical Standard Curve of Gp130/IL6ST elisa kit

Human GP130/IL6ST ELISA Kit, Typical Standard Curve – Cat# MBS763919

Other Notes

Small volumes of Gp130/IL6ST elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gp130/IL6ST purchase

MBS763919 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin-6 receptor subunit beta (Gp130/IL6ST) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Gp130/IL6ST. The ELISA analytical biochemical technique of the MBS763919 kit is based on Gp130/IL6ST antibody-Gp130/IL6ST antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Gp130/IL6ST antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Gp130/IL6ST. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for Gp130/IL6ST. It may not necessarily be applicable to this product.

NCBI GI #
225007625
NCBI GeneID
16195
NCBI Accession #
NP_034690.3
UniProt Secondary Accession #
G5E8D2
UniProt Related Accession #
Q00560
GenBank Nucleotide #
NM_010560.3
NCBI Official Full Name
interleukin-6 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Symbol
Il6st
NCBI Official Synonym Symbols
CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
UniProt Protein Name
Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names
Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
Protein Family
Interleukin-6 receptor
UniProt Gene Name
Il6st
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
UniProt Entry Name
IL6RB_MOUSE
NCBI Protein Information
interleukin-6 receptor subunit beta

UniProt Comments for Gp130/IL6ST

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: cell soma; cytosol; dendrite; external side of plasma membrane; extracellular space; integral to membrane; interleukin-6 receptor complex; membrane; oncostatin-M receptor complex; plasma membrane

Molecular Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 binding; interleukin-11 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; protein heterodimerization activity

Biological Process: cytokine and chemokine mediated signaling pathway; glycogen metabolic process; leukemia inhibitory factor signaling pathway; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of smooth muscle cell migration; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; reduction of cytosolic calcium ion concentration; regulation of Notch signaling pathway; response to cytokine stimulus; signal transduction; triacylglycerol mobilization
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Research Articles on Gp130/IL6ST

1. differences exist in the expression of receptors utilized by the IL-6/gp130 family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M by astrocytes versus microglia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Gp130/IL6ST elisa kit

 Reference Product  PubMed Publications
 Lif elisa kit  >239 publications with Gp130/IL6ST and Lif
 Cntf elisa kit  >112 publications with Gp130/IL6ST and Cntf
 Jak1 elisa kit  >55 publications with Gp130/IL6ST and Jak1
 Il6 elisa kit  >54 publications with Gp130/IL6ST and Il6
 Jak2 elisa kit  >48 publications with Gp130/IL6ST and Jak2
 Socs3 elisa kit  >37 publications with Gp130/IL6ST and Socs3
 Ptpn11 elisa kit  >32 publications with Gp130/IL6ST and Ptpn11
 Tyk2 elisa kit  >21 publications with Gp130/IL6ST and Tyk2
 Jak3 elisa kit  >6 publications with Gp130/IL6ST and Jak3
 Il6ra elisa kit  >1 publications with Gp130/IL6ST and Il6ra

Pathways associated with Gp130/IL6ST elisa kit

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram

Diseases associated with Gp130/IL6ST elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >123 publications with Gp130/IL6ST and Inflammation
 Cardiovascular Diseases Antibodies  >104 publications with Gp130/IL6ST and Cardiovascular Diseases
 Carcinoma Antibodies  >62 publications with Gp130/IL6ST and Carcinoma
 Disease Models, Animal Antibodies  >56 publications with Gp130/IL6ST and Disease Models, Animal
 Nervous System Diseases Antibodies  >54 publications with Gp130/IL6ST and Nervous System Diseases
 Heart Diseases Antibodies  >48 publications with Gp130/IL6ST and Heart Diseases
 Necrosis Antibodies  >46 publications with Gp130/IL6ST and Necrosis
 Liver Diseases Antibodies  >41 publications with Gp130/IL6ST and Liver Diseases
 Hypertrophy Antibodies  >31 publications with Gp130/IL6ST and Hypertrophy
 Liver Neoplasms Antibodies  >27 publications with Gp130/IL6ST and Liver Neoplasms

Organs/Tissues associated with Gp130/IL6ST elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >223 publications with Gp130/IL6ST and Blood
 Liver Antibodies  >93 publications with Gp130/IL6ST and Liver
 Bone Antibodies  >86 publications with Gp130/IL6ST and Bone
 Brain Antibodies  >81 publications with Gp130/IL6ST and Brain
 Heart Antibodies  >73 publications with Gp130/IL6ST and Heart
 Bone Marrow Antibodies  >60 publications with Gp130/IL6ST and Bone Marrow
 Lung Antibodies  >35 publications with Gp130/IL6ST and Lung
 Embryonic Tissue Antibodies  >34 publications with Gp130/IL6ST and Embryonic Tissue
 Kidney Antibodies  >19 publications with Gp130/IL6ST and Kidney
 Joint Antibodies  >17 publications with Gp130/IL6ST and Joint
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