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Erythropoietin Receptor (EPOR) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764028

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-human EPORantibody was pre-coated onto 96-well plates. And the biotin conjugated anti-human EPOR antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Erythropoietin receptor (EPOR), ELISA Kit
Full Product Name
Human Erythropoietin receptor ELISA Kit
Product Gene Name
EPOR elisa kit
Product Synonym Names
EPOR/EpoR/EPO-R/erythropoietin receptor
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
35,809 Da
OMIM
133100
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of EPOR elisa kit

Human EPOR ELISA Kit – Cat# MBS764028

Typical Standard Curve of EPOR elisa kit

Human EPOR ELISA Kit, Typical Standard Curve – Cat# MBS764028

Other Notes

Small volumes of EPOR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPOR purchase

MBS764028 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Erythropoietin receptor (EPOR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EPOR. The ELISA analytical biochemical technique of the MBS764028 kit is based on EPOR antibody-EPOR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EPOR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EPOR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for EPOR. It may not necessarily be applicable to this product.

NCBI GI #
4503591
NCBI GeneID
2057
NCBI Accession #
NP_000112.1
UniProt Secondary Accession #
Q15443; Q2M205; B2RCG4
UniProt Related Accession #
P19235
GenBank Nucleotide #
NM_000121.3
NCBI Official Full Name
erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
EPOR
NCBI Official Synonym Symbols
EPO-R
UniProt Protein Name
Erythropoietin receptor
Protein Family
Erythropoietin receptor
UniProt Gene Name
EPOR
UniProt Synonym Gene Names
EPO-R
UniProt Entry Name
EPOR_HUMAN
NCBI Protein Information
erythropoietin receptor

NCBI Summary for EPOR

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for EPOR

EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: cytosol; external side of plasma membrane; extracellular region; integral to plasma membrane

Molecular Function: erythropoietin receptor activity; identical protein binding; protein binding

Biological Process: brain development; decidualization; elevation of cytosolic calcium ion concentration; heart development; negative regulation of neuron apoptosis; positive regulation of cell proliferation; signal transduction

Disease: Erythrocytosis, Familial, 1
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Research Articles on EPOR

1. Data show that erythropoietin receptor antagonist EMP9 suppressed hemoglobin synthesis in xenografts of HeLa cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EPOR elisa kit

 Reference Product  PubMed Publications
 EPO elisa kit  >772 publications with EPOR and EPO
 JAK2 elisa kit  >201 publications with EPOR and JAK2
 KIT elisa kit  >52 publications with EPOR and KIT
 STAT5A elisa kit  >14 publications with EPOR and STAT5A
 GRB2 elisa kit  >10 publications with EPOR and GRB2
 STAT5B elisa kit  >9 publications with EPOR and STAT5B
 LYN elisa kit  >7 publications with EPOR and LYN
 CRKL elisa kit  >6 publications with EPOR and CRKL

Pathways associated with EPOR elisa kit

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with EPOR elisa kit

 Disease Name  Pubmed Publications
 Anemia Antibodies  >181 publications with EPOR and Anemia
 Polycythemia Antibodies  >82 publications with EPOR and Polycythemia
 Cardiovascular Diseases Antibodies  >79 publications with EPOR and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >74 publications with EPOR and Disease Models, Animal
 Kidney Diseases Antibodies  >46 publications with EPOR and Kidney Diseases
 Inflammation Antibodies  >39 publications with EPOR and Inflammation
 Necrosis Antibodies  >36 publications with EPOR and Necrosis
 Neoplasms, Experimental Antibodies  >33 publications with EPOR and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >32 publications with EPOR and Breast Neoplasms
 Adenocarcinoma Antibodies  >29 publications with EPOR and Adenocarcinoma

Organs/Tissues associated with EPOR elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >372 publications with EPOR and Blood
 Bone Antibodies  >147 publications with EPOR and Bone
 Brain Antibodies  >124 publications with EPOR and Brain
 Kidney Antibodies  >102 publications with EPOR and Kidney
 Liver Antibodies  >79 publications with EPOR and Liver
 Heart Antibodies  >51 publications with EPOR and Heart
 Embryonic Tissue Antibodies  >34 publications with EPOR and Embryonic Tissue
 Lung Antibodies  >31 publications with EPOR and Lung
 Eye Antibodies  >26 publications with EPOR and Eye
 Skin Antibodies  >13 publications with EPOR and Skin
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