Adenylate Cyclase Type 10 (ADCY10) ELISA Kit for Rat

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

SAC: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2). Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adenylyl cyclase; Lyase; Nucleotide Metabolism - purine; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: apical part of cell; axon; cell soma; cytoplasm; cytosol; dendrite; growth cone; microtubule cytoskeleton; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: adenylate cyclase activity; ATP binding; ATPase binding; magnesium ion binding; manganese ion binding

Biological Process: cAMP biosynthetic process; positive regulation of apoptosis; spermatogenesis

Disease: Hypercalciuria, Absorptive, 2