Adenosine A1 Receptor (ADORA1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Apoptosis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: asymmetric synapse; axolemma; basolateral plasma membrane; cell soma; dendritic spine; endoplasmic reticulum; integral to plasma membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane; terminal button

Molecular Function: adenosine receptor activity, G-protein coupled; G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; heat shock protein binding; heterotrimeric G-protein binding; phospholipase C activity; protein binding; protein heterodimerization activity; purine nucleoside binding

Biological Process: activation of MAPKK activity; adenosine receptor signaling pathway; cell-cell signaling; cognition; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response; lipid catabolic process; negative regulation of acute inflammatory response; negative regulation of apoptosis; negative regulation of blood pressure; negative regulation of cell proliferation; negative regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of glutamate secretion; negative regulation of hormone secretion; negative regulation of leukocyte migration; negative regulation of lipid catabolic process; negative regulation of neurotrophin production; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; negative regulation of vasodilation; nervous system development; neurological control of breathing; phagocytosis; positive regulation of blood pressure; positive regulation of epidermal growth factor receptor activity; positive regulation of nucleoside transport; positive regulation of peptide secretion; positive regulation of potassium ion transport; positive regulation of protein amino acid dephosphorylation; protein targeting to membrane; regulation of excitatory postsynaptic membrane potential; regulation of glomerular filtration; regulation of sensory perception of pain; relaxation of vascular smooth muscle; response to hypoxia; signal transduction; thermoregulation