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ALKBH3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS766544

MBS766544 is an antibody targeting ALKBH3. Also known as ALKBH3 Rabbit Polyclonal. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ALKBH3, Polyclonal Antibody
Full Product Name
ALKBH3 Rabbit Polyclonal
Product Gene Name
anti-ALKBH3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
19,310 Da
OMIM
610603
Immunogen
AlkB, alkylation repair homolog 3 (E. coli)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ALKBH3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-ALKBH3 antibody

Immunohistochemistry of paraffin-embedded human lung cancer using MBS766544 (ALKBH3 antibody) at dilution of 1:50
Rabbit Anti-ALKBH3 Polyclonal Antibody – Cat# MBS766544

Western Blot (WB) of anti-ALKBH3 antibody

mouse heart tissue were subjected to SDS PAGE followed by western blot with MBS766544 (ALKBH3 antibody) at dilution of 1:1000
Rabbit Anti-ALKBH3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS766544

Other Notes

Small volumes of anti-ALKBH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALKBH3. It may not necessarily be applicable to this product.

NCBI GI #
21040275
NCBI GeneID
221120
NCBI Accession #
NP_631917.1
UniProt Secondary Accession #
Q3SYI0; Q6NX57; Q96BU8; A6NDJ1
UniProt Related Accession #
Q96Q83
GenBank Nucleotide #
NM_139178.3
NCBI Official Full Name
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
NCBI Official Synonym Full Names
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
NCBI Official Symbol
ALKBH3
NCBI Official Synonym Symbols
ABH3; PCA1; DEPC1; hABH3; DEPC-1
UniProt Protein Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 3
Protein Family
Alpha-ketoglutarate-dependent dioxygenase
UniProt Gene Name
ALKBH3
UniProt Synonym Gene Names
; hABH3
UniProt Entry Name
ALKB3_HUMAN
NCBI Protein Information
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

NCBI Summary for ALKBH3

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
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UniProt Comments for ALKBH3

ALKBH3: Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; Hydrolase; DNA repair, damage; Oxidoreductase; EC 1.14.11.-

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: cytoplasm; mitochondrion; nucleoplasm; nucleus

Molecular Function: DNA demethylase activity; DNA-N1-methyladenine dioxygenase activity; ferrous iron binding; L-ascorbic acid binding; protein binding

Biological Process: cell proliferation; DNA dealkylation; DNA repair
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Research Articles on ALKBH3

1. Results show that PCA1 expression was positively correlated with advanced stages in renal cell carcinoma and strongly suggest that PCA-1 may be functionally important and a novel molecular target for human renal cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALKBH3 antibody

 Reference Product  PubMed Publications
 ALKBH1 antibody  >6 publications with ALKBH3 and ALKBH1
 ALKBH7 antibody  >1 publications with ALKBH3 and ALKBH7
 ALKBH4 antibody  >1 publications with ALKBH3 and ALKBH4
 VEGFA antibody  >1 publications with ALKBH3 and VEGFA
 ALKBH8 antibody  >1 publications with ALKBH3 and ALKBH8

Pathways associated with anti-ALKBH3 antibody

 Products by Pathway  Pathway Diagram
 ALKBH3 Mediated Reversal Of Alkylation Damage Pathway antibodies  ALKBH3 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram

Diseases associated with anti-ALKBH3 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >4 publications with ALKBH3 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >2 publications with ALKBH3 and Adenocarcinoma
 Obesity Antibodies  >2 publications with ALKBH3 and Obesity
 Respiratory Tract Diseases Antibodies  >1 publications with ALKBH3 and Respiratory Tract Diseases
 Prostatic Hyperplasia Antibodies  >1 publications with ALKBH3 and Prostatic Hyperplasia
 Kidney Diseases Antibodies  >1 publications with ALKBH3 and Kidney Diseases
 Inflammation Antibodies  >1 publications with ALKBH3 and Inflammation
 Hyperplasia Antibodies  >1 publications with ALKBH3 and Hyperplasia
 Necrosis Antibodies  >1 publications with ALKBH3 and Necrosis

Organs/Tissues associated with anti-ALKBH3 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >7 publications with ALKBH3 and Prostate
 Bladder Antibodies  >1 publications with ALKBH3 and Bladder
 Pancreas Antibodies  >1 publications with ALKBH3 and Pancreas
 Kidney Antibodies  >1 publications with ALKBH3 and Kidney
 Intestine Antibodies  >1 publications with ALKBH3 and Intestine
 Lung Antibodies  >1 publications with ALKBH3 and Lung
 Brain Antibodies  >1 publications with ALKBH3 and Brain
 Vascular Antibodies  >1 publications with ALKBH3 and Vascular
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