Apolipoprotein H (APOH) Antibody – Mouse Monoclonal

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cell surface; chylomicron; extracellular matrix; extracellular region; extracellular space

Molecular Function: glycoprotein binding; identical protein binding; lipid binding; phospholipid binding; protein binding

Biological Process: blood coagulation, intrinsic pathway; negative regulation of angiogenesis; negative regulation of blood coagulation; negative regulation of endothelial cell proliferation; negative regulation of fibrinolysis; negative regulation of myeloid cell apoptosis; plasminogen activation; platelet degranulation; positive regulation of blood coagulation; positive regulation of lipoprotein lipase activity; regulation of fibrinolysis; triacylglycerol metabolic process; triacylglycerol transport