ARF4 Antibody – Rabbit Polyclonal

This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

ARF4: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: cytosol; dendritic spine; Golgi apparatus; membrane

Molecular Function: ARF guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding; GTP binding; GTPase activity; protein binding

Biological Process: apical protein localization; brain development; cell migration; epidermal growth factor receptor signaling pathway; ER to Golgi vesicle-mediated transport; establishment and/or maintenance of epithelial cell polarity; learning; negative regulation of apoptosis; phospholipase D activation; positive regulation of GTPase activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid ADP-ribosylation; protein transport; response to axon injury; retrograde vesicle-mediated transport, Golgi to ER; small GTPase mediated signal transduction