ASIC2 Antibody – Rabbit Polyclonal

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis; Transporter; Membrane protein, multi-pass; Channel, cation; Transporter, ion channel

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cell soma; dendritic spine; integral to plasma membrane; plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; ion gated channel activity; protein binding

Biological Process: central nervous system development; detection of mechanical stimulus involved in sensory perception; monovalent inorganic cation transport; negative regulation of apoptosis; peripheral nervous system development; phototransduction; positive regulation of synaptogenesis; regulation of blood coagulation; regulation of gene expression; regulation of membrane potential; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; regulation of vasoconstriction; response to acidity; sensory perception of sound; sensory perception of sour taste; synaptic transmission