BACH1 Antibody – Rabbit Polyclonal

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

BACH1: a transcriptional regulator that acts as a repressor or activator. Binds, in-vitro, to NF-E2 binding sites on DNA. Plays an important role in coordinating transcription activation and repression by NF-E2. Belongs to the bZIP family, CNC subfamily.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: heme binding; protein binding; transcription factor activity; ubiquitin-protein ligase activity

Biological Process: DNA repair; G1/S-specific transcription in mitotic cell cycle; G2/M-specific transcription in mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; protein ubiquitination; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter