CD38 Antibody – Mouse Monoclonal

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; Hydrolase; Membrane protein, integral; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell cycle regulation; Apoptosis; EC 3.2.2.6; Cell surface; EC 2.4.99.20

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; cytosol; integral to membrane; membrane; nucleus; plasma membrane

Molecular Function: NAD(P)+ nucleosidase activity; NAD+ nucleosidase activity; phosphorus-oxygen lyase activity; transferase activity

Biological Process: B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; female pregnancy; metabolic process; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of insulin secretion; positive regulation of transcription, DNA-dependent; positive regulation of vasoconstriction; response to drug; response to estradiol stimulus; response to hydroperoxide; response to hypoxia; response to progesterone stimulus; response to retinoic acid; signal transduction