CRM1 Antibody – Rabbit Polyclonal

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Exportin-1: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. Belongs to the exportin family.

Protein type: Nuclear export; Karyopherin; Nuclear import; Nucleolus

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: annulate lamellae; Cajal body; cytoplasm; cytosol; intracellular membrane-bound organelle; kinetochore; membrane; nuclear envelope; nuclear membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: nucleocytoplasmic transporter activity; protein binding; protein domain specific binding; protein transporter activity; Ran GTPase binding; RNA binding; transporter activity

Biological Process: mRNA transport; negative regulation of transcription from RNA polymerase II promoter; protein export from nucleus; regulation of mRNA stability; regulation of protein catabolic process; regulation of protein export from nucleus; response to drug; ribosomal large subunit export from nucleus; ribosomal small subunit export from nucleus; sister chromatid cohesion; viral reproduction