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DMC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768654

MBS768654 is an antibody targeting DMC1. Also known as DMC1 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DMC1, Polyclonal Antibody
Full Product Name
DMC1 Rabbit Polyclonal
Product Gene Name
anti-DMC1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
31,559 Da
OMIM
602721
3D Structure
ModBase 3D Structure for Q14565
Immunogen
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-DMC1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-DMC1 antibody

Immunohistochemistry of paraffin-embedded human ovary tumor using MBS768654 (DMC1 antibody) at dilution of 1:100
Rabbit Anti-DMC1 Polyclonal Antibody – Cat# MBS768654

Immunoprecipitation (IP) of anti-DMC1 antibody

IP Result of anti-DMC1 (IP: MBS768654, 3ug; Detection: MBS768654 1:600) with mouse testis tissue lysate 4800ug.
Rabbit Anti-DMC1 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS768654

Western Blot (WB) of anti-DMC1 antibody

Hela cells were subjected to SDS PAGE followed by western blot with MBS768654 (DMC1 antibody) at dilution of 1:600
Rabbit Anti-DMC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768654

Other Notes

Small volumes of anti-DMC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DMC1. It may not necessarily be applicable to this product.

NCBI GI #
47678503
NCBI GeneID
11144
NCBI Accession #
CAG30372.1
UniProt Primary Accession #
Q14565
UniProt Secondary Accession #
Q08AI1; Q99498; Q9UH11; A8K9A2; B4DMW6
UniProt Related Accession #
Q14565
NCBI Official Full Name
DMC1
NCBI Official Synonym Full Names
DNA meiotic recombinase 1
NCBI Official Symbol
DMC1
NCBI Official Synonym Symbols
DMC1H; LIM15; dJ199H16.1
UniProt Protein Name
Meiotic recombination protein DMC1/LIM15 homolog
Protein Family
Meiotic recombination protein
UniProt Gene Name
DMC1
UniProt Synonym Gene Names
DMC1H; LIM15
UniProt Entry Name
DMC1_HUMAN
NCBI Protein Information
meiotic recombination protein DMC1/LIM15 homolog

NCBI Summary for DMC1

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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UniProt Comments for DMC1

DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.

Protein type: Cell development/differentiation; DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: chromosome; chromosome, telomeric region; condensed nuclear chromosome; nucleoplasm; nucleus

Molecular Function: ATP binding; DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding

Biological Process: DNA recombinase assembly; female gamete generation; male meiosis I; meiosis; meiotic recombination; mitotic recombination; oocyte maturation; ovarian follicle development; response to ionizing radiation; spermatid development; spermatogenesis; strand invasion; synapsis
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Research Articles on DMC1

1. In contrast to RAD51, stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DMC1 antibody

 Reference Product  PubMed Publications
 RAD51 antibody  >256 publications with DMC1 and RAD51
 BRCA2 antibody  >20 publications with DMC1 and BRCA2
 ATM antibody  >13 publications with DMC1 and ATM
 RAD50 antibody  >11 publications with DMC1 and RAD50
 RAD54B antibody  >6 publications with DMC1 and RAD54B
 BLM antibody  >6 publications with DMC1 and BLM
 FANCM antibody  >3 publications with DMC1 and FANCM
 RPA1 antibody  >3 publications with DMC1 and RPA1
 MRE11A antibody  >2 publications with DMC1 and MRE11A

Pathways associated with anti-DMC1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Recombination Pathway antibodies  Meiotic Recombination Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram

Diseases associated with anti-DMC1 antibody

 Disease Name  Pubmed Publications
 Aneuploidy Antibodies  >6 publications with DMC1 and Aneuploidy
 Kidney Diseases Antibodies  >5 publications with DMC1 and Kidney Diseases
 Congenital Abnormalities Antibodies  >3 publications with DMC1 and Congenital Abnormalities
 Testicular Diseases Antibodies  >3 publications with DMC1 and Testicular Diseases
 Urogenital Abnormalities Antibodies  >2 publications with DMC1 and Urogenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with DMC1 and Abnormalities, Multiple
 Uterine Cervical Neoplasms Antibodies  >1 publications with DMC1 and Uterine Cervical Neoplasms
 Lung Diseases Antibodies  >1 publications with DMC1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >1 publications with DMC1 and Neoplasms, Experimental
 Embryo Loss Antibodies  >1 publications with DMC1 and Embryo Loss

Organs/Tissues associated with anti-DMC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >48 publications with DMC1 and Testis
 Ovary Antibodies  >25 publications with DMC1 and Ovary
 Blood Antibodies  >10 publications with DMC1 and Blood
 Embryonic Tissue Antibodies  >5 publications with DMC1 and Embryonic Tissue
 Brain Antibodies  >3 publications with DMC1 and Brain
 Thymus Antibodies  >2 publications with DMC1 and Thymus
 Eye Antibodies  >1 publications with DMC1 and Eye
 Heart Antibodies  >1 publications with DMC1 and Heart
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