FBXO18 Antibody – Rabbit Polyclonal

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: chromatin; nucleus; SCF ubiquitin ligase complex

Molecular Function: 3'-5' DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; DNA helicase activity; DNA translocase activity; double-stranded DNA binding; protein binding; single-stranded DNA binding

Biological Process: cell death; DNA catabolic process, endonucleolytic; DNA duplex unwinding; double-strand break repair via homologous recombination; positive regulation of protein amino acid phosphorylation; protein ubiquitination; replication fork processing; replication fork protection; response to DNA damage stimulus