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ASIC1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS800065

Background Info: Detects ~60kDaScientific Background: Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests… More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ASIC1, Monoclonal Antibody
Full Product Name
ASIC1 Antibody: ATTO 390
Product Gene Name
anti-Asic1 antibody
Product Synonym Names
ACCN2; Acid-sensing (proton-gated) ion channel; Acid-sensing ion channel 1; Amiloride-sensitive cation channel 2 neuronal; BNAC2; Brain sodium channel 2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S271-44
Host
Mouse
Species Reactivity
Rat, Mouse
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Matching Pairs
Unconjugated Antibody: N/A (MBS800065)
ATTO 390 Conjugated Antibody: ASIC1 Clone #S271-44 (MBS800065)
Matching Pairs
Unconjugated Antibody: ASIC1 Clone #S271-44 (MBS802073)
ATTO 390 Conjugated Antibody: ASIC1 Clone #S271-44 (MBS800065)
Molecular Weight
62,309 Da
3D Structure
ModBase 3D Structure for Q6NXK8
Conjugate
ATTO 390
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-Asic1 antibody

Ion Channels
Applications Tested/Suitable for anti-Asic1 antibody
Immunocytochemistry (ICC), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Asic1 antibody
1:1000 WB

Western Blot (WB) of anti-Asic1 antibody

Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody at 1:100, 1:250, 1:500, and 1:1000.
Mouse Anti-ASIC1 Monoclonal Antibody – Cat# MBS800065

Product References and Citations for anti-Asic1 antibody

1. Garcia-Anoveros J., Derfler B., Neville-Golden J., Hyman B.T. and Corey D.P. (1997) Proc. Natl. Acad. Sci. USA 94: 1459-1464. 2. Waldmann R., Champigny G., Bassilana F., Heurteaux C. and Lazdunski M. (1997) Nature. 386: 173-177. 3. Grunder S., Geisler H.S., Rainier S. and Fink J.K. (2001) Eur. J. Hum. Genet. 9:672-676. 4. Chen C.C., Zimmer A., Sun W.H., Hall J., Brownstein M.J. and Zimmer A. (2002) Proc. Natl. Acad. Sci. USA 99: 8992-8997. 5. Wemmie J.A., et al. (2004) Proc. Natl. Acad. Sci. USA 101: 3621-3626.

Other Notes

Small volumes of anti-Asic1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Asic1 purchase

MBS800065 is an antibody targeting Asic1. Also known as ASIC1 Antibody: ATTO 390. Reactive in Rat, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Asic1. It may not necessarily be applicable to this product.

NCBI GI #
45433493
NCBI GeneID
11419
NCBI Accession #
NP_033727.1
UniProt Primary Accession #
Q6NXK8
UniProt Secondary Accession #
Q50K97
UniProt Related Accession #
Q6NXK8
GenBank Nucleotide #
NM_009597.1
NCBI Official Full Name
acid-sensing ion channel 1 isoform 2
NCBI Official Synonym Full Names
acid-sensing (proton-gated) ion channel 1
NCBI Official Symbol
Asic1
NCBI Official Synonym Symbols
ASIC; Accn2; BNaC2; ASIC1a; AI843610; B530003N02Rik
UniProt Protein Name
Acid-sensing ion channel 1
UniProt Synonym Protein Names
Acid-sensing ion channel; Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2
Protein Family
Acid-sensing ion channel
UniProt Gene Name
Asic1
UniProt Synonym Gene Names
Accn2; Asic; Bnac2; ASIC1; BNaC2
UniProt Entry Name
ASIC1_MOUSE
NCBI Protein Information
acid-sensing ion channel 1; degenerin 2; brain sodium channel 2; acid sensing ion channel; amiloride-sensitive cation channel 2, neuronal

UniProt Comments for Asic1

ASIC1: non-voltage-gated amiloride-sensitive cation channel permeable for sodium, potassium and lithium. A member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Expressed in most if not all brain neurons.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, cation

Cellular Component: cell surface; membrane; integral to plasma membrane; dendritic spine; integral to membrane; plasma membrane; synapse; dendritic shaft

Molecular Function: amiloride-sensitive sodium channel activity; monovalent inorganic cation transmembrane transporter activity; protein binding; ion gated channel activity; ion channel activity; cation channel activity; sodium channel activity

Biological Process: regulation of membrane potential; transport; calcium ion transport; sodium ion transport; monovalent inorganic cation transport; ion transport; sensory perception of sour taste; response to acidity; cation transport; associative learning; memory; negative regulation of neurotransmitter secretion
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Research Articles on Asic1

1. Data suggest that mitochondrial ASIC1a may serve as an important regulator of MPT pores, which contributes to oxidative neuronal cell death.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Asic1 antibody

 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-Asic1 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >281 publications with Asic1 and Pain
 Nervous System Diseases Antibodies  >212 publications with Asic1 and Nervous System Diseases
 Acidosis Antibodies  >207 publications with Asic1 and Acidosis
 Inflammation Antibodies  >111 publications with Asic1 and Inflammation
 Cerebral Infarction Antibodies  >73 publications with Asic1 and Cerebral Infarction
 Stroke Antibodies  >73 publications with Asic1 and Stroke
 Brain Ischemia Antibodies  >68 publications with Asic1 and Brain Ischemia
 Hyperalgesia Antibodies  >55 publications with Asic1 and Hyperalgesia
 Seizures Antibodies  >21 publications with Asic1 and Seizures
 Heart Diseases Antibodies  >18 publications with Asic1 and Heart Diseases

Organs/Tissues associated with anti-Asic1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >283 publications with Asic1 and Brain
 Heart Antibodies  >63 publications with Asic1 and Heart
 Spinal Cord Antibodies  >48 publications with Asic1 and Spinal Cord
 Eye Antibodies  >18 publications with Asic1 and Eye
 Embryonic Tissue Antibodies  >17 publications with Asic1 and Embryonic Tissue
 Inner Ear Antibodies  >11 publications with Asic1 and Inner Ear
 Bone Marrow Antibodies  >4 publications with Asic1 and Bone Marrow
 Spleen Antibodies  >2 publications with Asic1 and Spleen
 Thyroid Antibodies  >1 publications with Asic1 and Thyroid
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