P33 ING1 (ING1) Antibody – Rabbit Polyclonal

Background Info: Detects a ~33kDa protein corresponding to the molecular mass of p33 ING1 on SDS PAGE immunoblots. Not cross-reactive with any other ING family.

Scientific Background: The p33ING1 protein encodes a 33-kD, 294-amino acid protein that displays the characteristics of a tumor suppressor gene. The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. It can mediate growth arrest, anchor dependent growth and influence chemo sensitivity (1-4). It also has a proposed role as a growth regulator, which is consistent with its location in the nucleus (5). It has been demonstrated that the ING1 gene has three exons and that four mRNA variants are transcribed from three different promoter regions (p33 ING1, p24 ING1, p27 ING1, p47 IG1) (6, 7). ING1 can possibly influence the above biological functions depending on which variant is expressed (1-4).

1. Cheung, K.J., Jr. and Li, G. (2002) Int. J. Oncol. 21(6): 1361-1365. 2. Cheung, K.J., Jr. and Li, G. (2002) Exp. Cell Res. 279(2): 291-28. 3. Cheung, K.J., Jr. and Li, G. (2002) Int. J. Oncol. 20(6):1319-1322. 4. Cheung, K.J., Jr. and Li, G. (2001) Exp. Cell Res. 268(1): 1-6. 5. Garkavtsev, I. et al. (1996). Nat Genet. 14 (4): 415-420. 6. Gunduz, M. et al. (2000). Cancer Res. 60 (12): 3143-6. 7. Jager, D. et al. (1999). Cancer Res. 59: 6197- 6204.

Small volumes of anti-Ing1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS805353 is an antibody targeting Ing1. Also known as p33 ING1 Antibody: ATTO 594. Reactive in Human, Mouse. Host: Rabbit.