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SLC9A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS806370

Background Info: Detects ~84kDaScientific Background: Sodium-hydrogen exchanger 3 (NHE3; Slc9a3) is an epithelial transport protein that carries out 1:1 exchange of Na+ and H+ across the plasma membrane. It is apically located in the proximal tubule of the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NHE3 (Slc9a3), Polyclonal Antibody
Full Product Name
NHE3 Antibody: FITC
Product Gene Name
anti-Slc9a3 antibody
Product Synonym Names
Slc9a3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat, Mouse
Form/Format
Affinity Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Matching Pairs
Unconjugated Antibody: N/A (MBS806370)
FITC Conjugated Antibody: NHE3 (MBS806370)
Matching Pairs
Unconjugated Antibody: NHE3 (MBS806469)
FITC Conjugated Antibody: NHE3 (MBS806370)
Molecular Weight
93,105 Da
3D Structure
ModBase 3D Structure for P26433
Conjugate
FITC
Storage Buffer
PBS, 50% glycerol, 0.09% sodium azide.

Product Categories/Family for anti-Slc9a3 antibody

Transporters
Applications Tested/Suitable for anti-Slc9a3 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-Slc9a3 antibody
1:1000 (WB)

Western Blot (WB) of anti-Slc9a3 antibody

Western blot analysis of Rat kidney tissue lysates showing detection of NHE3 protein using Rabbit Anti-NHE3 Polyclonal Antibody (SPC-400). Primary Antibody: Rabbit Anti-NHE3 Polyclonal Antibody (SPC-400) at 1:1000.
Rabbit Anti-SLC9A3 Polyclonal Antibody – Cat# MBS806370

Product References and Citations for anti-Slc9a3 antibody

1. Kim G.H., Ecelbarger C.A., Knepper M.A. and Packer R.K. (1999) J Am Soc Nephrol. 10: 935-942. 2. Dynia D.W., Steinmetz A.G. and Kocinsky H.S. (2010) Am J Physoil Renal Physiol. 298(3): F745-F753.

Other Notes

Small volumes of anti-Slc9a3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Slc9a3 purchase

MBS806370 is an antibody targeting Slc9a3. Also known as NHE3 Antibody: FITC. Reactive in Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Slc9a3. It may not necessarily be applicable to this product.

NCBI GI #
6981562
NCBI GeneID
24784
NCBI Accession #
NP_036786
UniProt Primary Accession #
P26433
UniProt Related Accession #
P26433
GenBank Nucleotide #
NM_012654.1
NCBI Official Full Name
sodium/hydrogen exchanger 3
NCBI Official Synonym Full Names
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
NCBI Official Symbol
Slc9a3
NCBI Official Synonym Symbols
Nhe3
UniProt Protein Name
Sodium/hydrogen exchanger 3
UniProt Synonym Protein Names
Na(+)/H(+) exchanger 3; NHE-3; Solute carrier family 9 member 3
Protein Family
Sodium/hydrogen exchanger
UniProt Gene Name
Slc9a3
UniProt Synonym Gene Names
Nhe3; NHE-3
UniProt Entry Name
SL9A3_RAT
NCBI Protein Information
sodium/hydrogen exchanger 3; NHE-3; Na(+)/H(+) exchanger 3; solute carrier family 9 member 3; solute carrier family 9, member 3; plasma membrane ion transport protein; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)

NCBI Summary for Slc9a3

displays Na+/H+ exchanger transport activity; mediates sodium ion transport across the renal proximal tubule [RGD, Feb 2006]

UniProt Comments for Slc9a3

NHE3: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass

Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane; brush border

Molecular Function: protein binding; sodium:hydrogen antiporter activity; PDZ domain binding

Biological Process: circadian rhythm; receptor-mediated endocytosis; response to glucocorticoid stimulus; sodium ion transport; regulation of pH; regulation of sodium ion transport
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Research Articles on Slc9a3

1. results indicate that central NHE3 might be a molecular target for sleep apnea treatment, whose inhibitors may be potential therapeutic drugs for sleep apnea.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Slc9a3 antibody

 Reference Product  PubMed Publications
 Cftr antibody  >5 publications with Slc9a3 and Cftr

Pathways associated with anti-Slc9a3 antibody

 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram

Diseases associated with anti-Slc9a3 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >5 publications with Slc9a3 and Fibrosis
 Inflammation Antibodies  >4 publications with Slc9a3 and Inflammation
 Hypertension Antibodies  >4 publications with Slc9a3 and Hypertension
 Kidney Diseases Antibodies  >2 publications with Slc9a3 and Kidney Diseases
 Intestinal Obstruction Antibodies  >2 publications with Slc9a3 and Intestinal Obstruction
 CYSTIC FIBROSIS, MODIFIER OF, 1 Antibodies  >2 publications with Slc9a3 and CYSTIC FIBROSIS, MODIFIER OF, 1
 Cardiovascular Abnormalities Antibodies  >1 publications with Slc9a3 and Cardiovascular Abnormalities
 Heart Failure Antibodies  >1 publications with Slc9a3 and Heart Failure
 Seizures Antibodies  >1 publications with Slc9a3 and Seizures
 Hyperglycemia Antibodies  >1 publications with Slc9a3 and Hyperglycemia
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