Rabbit Anti-ATG13 Polyclonal Antibody – Cat# MBS807414

ATG13 Antibody – Rabbit Polyclonal

Name: ATG13 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS807414
Price: 615 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS807414

ATG13 is an autophagy factor required for phagosome formation. It is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex (1-3). More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ATG13, Polyclonal Antibody

Full Product Name

Rabbit Anti-Human ATG13 Polyclonal

Product Gene Name

anti-ATG13 antibody

Product Synonym Names

ATG13_Human Antibody; Autophagy related protein 13 Antibody; KIAA0652 Antibody; ATG13 Antibody: HRP; Rabbit Anti-Human ATG13 Polyclonal; ATG13 Antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Peptide Affinity Purified

Concentration

1 mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C

Molecular Weight

Detects ~56-63kDa.

OMIM

615088

3D Structure

ModBase 3D Structure for O75143

Immunogen

Synthetic peptide from the mid-protein range of human ATG13

Immunogen Species

Human

COA

A 1:1000 dilution was sufficient for detection of ATG13 on HEK293 lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

Storage Buffer

PBS, 50% glycerol, 0.09% sodium azide

Conjugate

HRP

Cellular Localization

Cytoplasm, Cytosol, Preautophagosomal structure

Product Categories/Family for anti-ATG13 antibody

Cancer; Autophagy

Applications Tested/Suitable for anti-ATG13 antibody

Western Blot (WB)

Application Notes for anti-ATG13 antibody

Western Blot: 1:1000

Product References and Citations for anti-ATG13 antibody

1. Mercer C.A., Kaliappan A., Dennis P.B. (2009) Autophagy. 5(5): 649-662. 2. Hosokawa N., et al. (2009) Mol Biol Cell. 20(7): 1981-1991. 3. Chan E.Y., Longatti A., McKnight N.C., Tooze S.A. (2009) Mol Cell Biol. 29(1): 157-171.

Other Notes

Small volumes of anti-ATG13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATG13 purchase

MBS807414 is an antibody targeting ATG13. Also known as Rabbit Anti-Human ATG13 Polyclonal. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATG13. It may not necessarily be applicable to this product.

NCBI GI #

218082953

NCBI GeneID

9776

NCBI Accession #

NP_001136145.1

UniProt Primary Accession #

O75143

UniProt Secondary Accession #

Q53EN6; Q9BRL3; Q9H8B0; B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8

UniProt Related Accession #

O75143

GenBank Nucleotide #

NM_001142673.2

NCBI Official Full Name

autophagy-related protein 13 isoform 1

NCBI Official Synonym Full Names

autophagy related 13

NCBI Official Symbol

ATG13

NCBI Official Synonym Symbols

KIAA0652; PARATARG8

UniProt Protein Name

Autophagy-related protein 13

Protein Family

Autophagy protein

UniProt Gene Name

ATG13

UniProt Synonym Gene Names

KIAA0652

UniProt Entry Name

ATG13_HUMAN

NCBI Protein Information

autophagy-related protein 13

UniProt Comments for ATG13

ATG13: an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 and -2 via C-terminus. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Autophagy

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: cytosol; extrinsic to membrane; mitochondrion

Molecular Function: protein binding; protein kinase binding; protein kinase regulator activity

Biological Process: activation of protein kinase activity; autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy; mitochondrion degradation

Research Articles on ATG13

1. Specific affinity of the LC3 isoforms to the Atg13 LC3-interacting region is required for proper autophagosome formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ATG13 antibody

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Longevity Regulating Pathway - Mammal antibodies	Longevity Regulating Pathway - Mammal Diagram
Macroautophagy Pathway antibodies	Macroautophagy Pathway Diagram
Regulation Of Autophagy Pathway antibodies	Regulation Of Autophagy Pathway Diagram
Regulation Of Autophagy Pathway antibodies	Regulation Of Autophagy Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram
MTOR Signaling Pathway antibodies	MTOR Signaling Pathway Diagram

Diseases associated with anti-ATG13 antibody

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>5 publications with ATG13 and Kidney Diseases
Breast Neoplasms Antibodies	>3 publications with ATG13 and Breast Neoplasms
Atrophy Antibodies	>3 publications with ATG13 and Atrophy
Nervous System Diseases Antibodies	>3 publications with ATG13 and Nervous System Diseases
Necrosis Antibodies	>2 publications with ATG13 and Necrosis
Cognition Disorders Antibodies	>1 publications with ATG13 and Cognition Disorders
Mental Disorders Antibodies	>1 publications with ATG13 and Mental Disorders
Disease Models, Animal Antibodies	>1 publications with ATG13 and Disease Models, Animal
Embryo Loss Antibodies	>1 publications with ATG13 and Embryo Loss
Hypertrophy Antibodies	>1 publications with ATG13 and Hypertrophy

Organs/Tissues associated with anti-ATG13 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>7 publications with ATG13 and Muscle
Kidney Antibodies	>5 publications with ATG13 and Kidney
Vascular Antibodies	>4 publications with ATG13 and Vascular
Blood Antibodies	>3 publications with ATG13 and Blood
Liver Antibodies	>2 publications with ATG13 and Liver
Salivary Gland Antibodies	>1 publications with ATG13 and Salivary Gland
Eye Antibodies	>1 publications with ATG13 and Eye
Lung Antibodies	>1 publications with ATG13 and Lung