Adenylate Cyclase 5/6 (ADCY5) Antibody – Rabbit Polyclonal

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Lyase; EC 4.6.1.1; Nucleotide Metabolism - purine; Transporter; Membrane protein, integral; Adenylyl cyclase; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein heterodimerization activity; metal ion binding; ATP binding; adenylate cyclase activity; adenylate cyclase binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; locomotory behavior; signal transduction; G-protein signaling, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; synaptic transmission; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; neuromuscular process controlling balance; transmembrane transport; adenosine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway

Disease: Dyskinesia, Familial, With Facial Myokymia