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USP19 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820480

MBS820480 is an antibody targeting USP19. Reactive in Human, Rat, Rabbit. Host: Rabbit. Rabbit polyclonal antibody to USP19 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
USP19, Polyclonal Antibody
Full Product Name
Anti-USP19 Antibody
Product Gene Name
anti-USP19 antibody
Product Synonym Names
KIAA0891; ZMYND9; Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19; Zinc finger MYND domain-containing protein 9
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Rabbit
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of USP19 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
USP19 peptide (MBS823740) is used for blocking the activity of USP19 antibody (MBS820480)
Molecular Weight
150,659 Da
OMIM
614471
3D Structure
ModBase 3D Structure for O94966
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human USP19. The exact sequence is proprietary.
Applications Tested/Suitable for anti-USP19 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-USP19 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-USP19 antibody

Western blot analysis of USP19 expression in Jurkat (A), H9C2 (B) whole cell lysates.
Rabbit Anti-USP19 Polyclonal Antibody – Cat# MBS820480

Immunohistochemistry (IHC) of anti-USP19 antibody

Immunohistochemical analysis of USP19 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-USP19 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS820480

Other Notes

Small volumes of anti-USP19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for USP19. It may not necessarily be applicable to this product.

NCBI GI #
312596871
NCBI GeneID
10869
NCBI Accession #
NP_001186089.1
UniProt Primary Accession #
O94966
UniProt Secondary Accession #
Q3KQW4; Q641Q9; Q6NZY8; Q86XV9; A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8
UniProt Related Accession #
O94966
GenBank Nucleotide #
NM_001199160.1
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 19 isoform 1
NCBI Official Synonym Full Names
ubiquitin specific peptidase 19
NCBI Official Symbol
USP19
NCBI Official Synonym Symbols
ZMYND9
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 19
UniProt Synonym Protein Names
Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19; Zinc finger MYND domain-containing protein 9
UniProt Gene Name
USP19
UniProt Synonym Gene Names
KIAA0891; ZMYND9
UniProt Entry Name
UBP19_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 19; ubiquitin thioesterase 19; deubiquitinating enzyme 19; ubiquitin thiolesterase 19; ubiquitin specific protease 19; ubiquitin-specific-processing protease 19; zinc finger MYND domain-containing protein 9

UniProt Comments for USP19

USP19: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. Belongs to the peptidase C19 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Protease; Membrane protein, integral; EC 3.4.19.12; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: endoplasmic reticulum membrane; integral to membrane; cytosol

Molecular Function: protein binding; cysteine-type endopeptidase activity; metal ion binding; ubiquitin-specific protease activity

Biological Process: negative regulation of skeletal muscle development; ER-associated protein catabolic process; protein deubiquitination; regulation of protein stability
Show more

Research Articles on USP19

1. These results clarify the role of USP19 in ERAD and suggest a novel DUB regulation that involves chaperone association and membrane integration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-USP19 antibody

 Reference Product  PubMed Publications
 SIAH2 antibody  >1 publications with USP19 and SIAH2

Diseases associated with anti-USP19 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >7 publications with USP19 and Atrophy
 Prostatic Diseases Antibodies  >1 publications with USP19 and Prostatic Diseases
 Death Antibodies  >1 publications with USP19 and Death
 Fibrosis Antibodies  >1 publications with USP19 and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >1 publications with USP19 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >1 publications with USP19 and Necrosis

Organs/Tissues associated with anti-USP19 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >8 publications with USP19 and Muscle
 Vascular Antibodies  >1 publications with USP19 and Vascular
 Nerve Antibodies  >1 publications with USP19 and Nerve
 Prostate Antibodies  >1 publications with USP19 and Prostate
 Brain Antibodies  >1 publications with USP19 and Brain
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