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Cytochrome P450 2u1 (CYP2U1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS820601

MBS820601 is an antibody targeting CYP2U1. Also known as Anti-Cytochrome P450 2U1 Antibody. Reactive in Human, Monkey. Host: Rabbit. Rabbit polyclonal antibody to Cytochrome P450 2U1 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cytochrome P450 2U1 (CYP2U1), Polyclonal Antibody
Full Product Name
Anti-Cytochrome P450 2U1 Antibody
Product Gene Name
anti-CYP2U1 antibody
Product Synonym Names
Cytochrome P450 2U1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Cytochrome P450 2U1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
Cytochrome P450 2U1 peptide (MBS823137) is used for blocking the activity of Cytochrome P450 2U1 antibody (MBS820601)
Molecular Weight
18,578 Da
OMIM
gene 615030
3D Structure
ModBase 3D Structure for Q7Z449
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 2U1. The exact sequence is proprietary.
Applications Tested/Suitable for anti-CYP2U1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-CYP2U1 antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)

Western Blot (WB) of anti-CYP2U1 antibody

Western blot analysis of Cytochrome P450 2U1 expression in LOVO (A), A2058 (B) whole cell lysates.
Rabbit Anti-CYP2U1 Polyclonal Antibody – Cat# MBS820601

Immunohistochemistry (IHC) of anti-CYP2U1 antibody

Immunohistochemical analysis of Cytochrome P450 2U1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-CYP2U1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS820601

Immunofluorescence (IF) of anti-CYP2U1 antibody

Immunofluorescent analysis of Cytochrome P450 2U1 staining in LOVO cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-CYP2U1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS820601

Other Notes

Small volumes of anti-CYP2U1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP2U1. It may not necessarily be applicable to this product.

NCBI GI #
34098959
NCBI GeneID
113612
NCBI Accession #
NP_898898.1
UniProt Primary Accession #
Q7Z449
UniProt Secondary Accession #
Q96EQ6; B2RMV7
UniProt Related Accession #
Q7Z449
GenBank Nucleotide #
NM_183075.2
NCBI Official Full Name
cytochrome P450 2U1
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily U, polypeptide 1
NCBI Official Symbol
CYP2U1
NCBI Official Synonym Symbols
SPG49; SPG56; P450TEC
UniProt Protein Name
Cytochrome P450 2U1
Protein Family
Cytochrome
UniProt Gene Name
CYP2U1
UniProt Entry Name
CP2U1_HUMAN
NCBI Protein Information
cytochrome P450 2U1; spastic paraplegia 49

NCBI Summary for CYP2U1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYP2U1

CYP2U1: Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - arachidonic acid; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; EC 1.14.14.1

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane

Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; oxygen binding

Biological Process: organic acid metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process

Disease: Spastic Paraplegia 56, Autosomal Recessive
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Research Articles on CYP2U1

1. The CYP2U1 gene shows a low mutation frequency in a general population of complicated hereditary spastic paraparesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYP2U1 antibody

 Reference Product  PubMed Publications
 CYP2S1 antibody  >10 publications with CYP2U1 and CYP2S1
 CYP2J2 antibody  >4 publications with CYP2U1 and CYP2J2
 CYP4X1 antibody  >3 publications with CYP2U1 and CYP4X1
 CYP2B6 antibody  >1 publications with CYP2U1 and CYP2B6
 CYP4F3 antibody  >1 publications with CYP2U1 and CYP4F3
 CYP4A11 antibody  >1 publications with CYP2U1 and CYP4A11

Pathways associated with anti-CYP2U1 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Miscellaneous Substrates Pathway antibodies  Miscellaneous Substrates Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram

Diseases associated with anti-CYP2U1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >3 publications with CYP2U1 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >3 publications with CYP2U1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >2 publications with CYP2U1 and Neoplasms, Experimental
 Fatty Liver Antibodies  >2 publications with CYP2U1 and Fatty Liver
 Ovarian Neoplasms Antibodies  >1 publications with CYP2U1 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >1 publications with CYP2U1 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with CYP2U1 and Inflammation

Organs/Tissues associated with anti-CYP2U1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with CYP2U1 and Brain
 Liver Antibodies  >9 publications with CYP2U1 and Liver
 Thymus Antibodies  >6 publications with CYP2U1 and Thymus
 Lung Antibodies  >4 publications with CYP2U1 and Lung
 Vascular Antibodies  >3 publications with CYP2U1 and Vascular
 Intestine Antibodies  >2 publications with CYP2U1 and Intestine
 Skin Antibodies  >2 publications with CYP2U1 and Skin
 Ovary Antibodies  >2 publications with CYP2U1 and Ovary
 Kidney Antibodies  >2 publications with CYP2U1 and Kidney
 Embryonic Tissue Antibodies  >1 publications with CYP2U1 and Embryonic Tissue
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