SLC28A1 Antibody – Rabbit Polyclonal

SLC28A1: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: nucleoside transmembrane transporter activity; nucleoside:sodium symporter activity; nucleoside binding

Biological Process: nucleoside transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; transmembrane transport