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MC4 Receptor (MC4R) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821308

MBS821308 is an antibody targeting MC4R. Also known as Anti-MC4 Receptor Antibody. Reactive in Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Sheep. Host: Rabbit. Rabbit polyclonal antibody to MC4 Receptor More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MC4 Receptor (MC4R), Polyclonal Antibody
Full Product Name
Anti-MC4 Receptor Antibody
Product Gene Name
anti-MC4R antibody
Product Synonym Names
Melanocortin receptor 4; MC4-R
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Sheep
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of MC4 Receptor protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
MC4 Receptor peptide (MBS822792) is used for blocking the activity of MC4 Receptor antibody (MBS821308)
Molecular Weight
36,943 Da
OMIM
gene 601665
3D Structure
ModBase 3D Structure for P32245
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MC4 Receptor. The exact sequence is proprietary.
Applications Tested/Suitable for anti-MC4R antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MC4R antibody
WB (1/500 - 1/1000), IH (1/100 - 1/200)

Western Blot (WB) of anti-MC4R antibody

Western blot analysis of MC4 Receptor expression in EOC20 (A) whole cell lysates.
Rabbit Anti-MC4R Polyclonal Antibody – Cat# MBS821308

Immunohistochemistry (IHC) of anti-MC4R antibody

Immunohistochemical analysis of MC4 Receptor staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-MC4R Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821308

Other Notes

Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.

NCBI GI #
119508433
NCBI GeneID
4160
NCBI Accession #
NP_005903.2
UniProt Primary Accession #
P32245
UniProt Secondary Accession #
Q16317; Q3MIJ6; B2RAC3
UniProt Related Accession #
P32245
GenBank Nucleotide #
NM_005912.2
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Official Symbol
MC4R
UniProt Protein Name
Melanocortin receptor 4
Protein Family
Melanocortin receptor
UniProt Gene Name
MC4R
UniProt Synonym Gene Names
MC4-R
UniProt Entry Name
MC4R_HUMAN
NCBI Protein Information
melanocortin receptor 4; MC4-R

NCBI Summary for MC4R

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
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UniProt Comments for MC4R

MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: plasma membrane; integral to membrane; nucleus

Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity; ubiquitin protein ligase binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus

Disease: Obesity
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Research Articles on MC4R

1. No significant influence of the MC4R rs17782313 polymorphism on energy metabolism or biochemical variables in obese women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MC4R antibody

 Reference Product  PubMed Publications
 POMC antibody  >345 publications with MC4R and POMC
 AGRP antibody  >130 publications with MC4R and AGRP
 MC1R antibody  >75 publications with MC4R and MC1R
 LEP antibody  >24 publications with MC4R and LEP
 CRH antibody  >12 publications with MC4R and CRH
 GLP1R antibody  >3 publications with MC4R and GLP1R
 GHRH antibody  >1 publications with MC4R and GHRH

Pathways associated with anti-MC4R antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-MC4R antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >615 publications with MC4R and Obesity
 Body Weight Antibodies  >557 publications with MC4R and Body Weight
 Weight Gain Antibodies  >90 publications with MC4R and Weight Gain
 Weight Loss Antibodies  >81 publications with MC4R and Weight Loss
 Hyperphagia Antibodies  >70 publications with MC4R and Hyperphagia
 Insulin Resistance Antibodies  >54 publications with MC4R and Insulin Resistance
 Hyperinsulinism Antibodies  >45 publications with MC4R and Hyperinsulinism
 Cardiovascular Diseases Antibodies  >37 publications with MC4R and Cardiovascular Diseases
 Hypertension Antibodies  >37 publications with MC4R and Hypertension
 Inflammation Antibodies  >34 publications with MC4R and Inflammation

Organs/Tissues associated with anti-MC4R antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >290 publications with MC4R and Brain
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