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SLCO1A2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821836

MBS821836 is an antibody targeting SLCO1A2. Also known as Anti-OATP1 Antibody. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to OATP1 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OATP1 (SLCO1A2), Polyclonal Antibody
Full Product Name
Anti-OATP1 Antibody
Product Gene Name
anti-SLCO1A2 antibody
Product Synonym Names
OATP; OATP1; OATP1A2; SLC21A3; Solute carrier organic anion transporter family member 1A2; OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of OATP1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
OATP1 peptide (MBS822500) is used for blocking the activity of OATP1 antibody (MBS821836)
Molecular Weight
64,369 Da
OMIM
602883
3D Structure
ModBase 3D Structure for P46721
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human OATP1. The exact sequence is proprietary.
Applications Tested/Suitable for anti-SLCO1A2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-SLCO1A2 antibody
WB (1/500 - 1/1000), IP (1/10 - 1/100)

Western Blot (WB) of anti-SLCO1A2 antibody

Western blot analysis of OATP1 expression in Jurkat (A), MCF7 (B), SHSY5Y (C) whole cell lysates.
Rabbit Anti-SLCO1A2 Polyclonal Antibody – Cat# MBS821836

Immunohistochemistry (IHC) of anti-SLCO1A2 antibody

Rabbit Anti-SLCO1A2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS821836

Other Notes

Small volumes of anti-SLCO1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLCO1A2. It may not necessarily be applicable to this product.

NCBI GI #
10835099
NCBI GeneID
6579
NCBI Accession #
NP_066580.1
UniProt Primary Accession #
P46721
UniProt Secondary Accession #
Q9UGP7; Q9UL38
UniProt Related Accession #
P46721
GenBank Nucleotide #
NM_021094.3
NCBI Official Full Name
solute carrier organic anion transporter family member 1A2
NCBI Official Synonym Full Names
solute carrier organic anion transporter family, member 1A2
NCBI Official Symbol
SLCO1A2
NCBI Official Synonym Symbols
OATP; OATP-A; OATP1A2; SLC21A3
UniProt Protein Name
Solute carrier organic anion transporter family member 1A2
UniProt Synonym Protein Names
OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
Protein Family
Solute carrier organic anion transporter family
UniProt Gene Name
SLCO1A2
UniProt Synonym Gene Names
OATP; OATP1; OATP1A2; SLC21A3; OATP-1
UniProt Entry Name
SO1A2_HUMAN
NCBI Protein Information
solute carrier organic anion transporter family member 1A2; OATP-1; solute carrier family 21 member 3; organic anion transporting polypeptide A; organic anion-transporting polypeptide 1; sodium-independent organic anion transporter; solute carrier family 21 (organic anion transporter), member 3

NCBI Summary for SLCO1A2

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
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UniProt Comments for SLCO1A2

SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: plasma membrane; integral to membrane

Molecular Function: organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport
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Research Articles on SLCO1A2

1. Five novel single nucleotide polymorphisms (SNIP)S in the coding exons of SLCO1A2 gene transporter have been identified.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLCO1A2 antibody

 Reference Product  PubMed Publications
 SLC10A1 antibody  >5 publications with SLCO1A2 and SLC10A1
 ABCC3 antibody  >3 publications with SLCO1A2 and ABCC3
 ABCB11 antibody  >3 publications with SLCO1A2 and ABCB11
 SLC22A7 antibody  >1 publications with SLCO1A2 and SLC22A7

Pathways associated with anti-SLCO1A2 antibody

 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Recycling Of Bile Acids And Salts Pathway antibodies  Recycling Of Bile Acids And Salts Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Organic Anions Pathway antibodies  Transport Of Organic Anions Pathway Diagram
 Transport Of Vitamins, Nucleosides, And Related Molecules Pathway antibodies  Transport Of Vitamins, Nucleosides, And Related Molecules Pathway Diagram

Diseases associated with anti-SLCO1A2 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with SLCO1A2 and Liver Diseases
 Brain Diseases Antibodies  >7 publications with SLCO1A2 and Brain Diseases
 Breast Neoplasms Antibodies  >2 publications with SLCO1A2 and Breast Neoplasms
 Cholestasis, Intrahepatic Antibodies  >2 publications with SLCO1A2 and Cholestasis, Intrahepatic
 Cholestasis Antibodies  >2 publications with SLCO1A2 and Cholestasis
 Neoplasms, Experimental Antibodies  >1 publications with SLCO1A2 and Neoplasms, Experimental
 Lymphoma Antibodies  >1 publications with SLCO1A2 and Lymphoma
 Fibrosis Antibodies  >1 publications with SLCO1A2 and Fibrosis
 Renal Insufficiency Antibodies  >1 publications with SLCO1A2 and Renal Insufficiency

Organs/Tissues associated with anti-SLCO1A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >21 publications with SLCO1A2 and Liver
 Brain Antibodies  >18 publications with SLCO1A2 and Brain
 Kidney Antibodies  >15 publications with SLCO1A2 and Kidney
 Prostate Antibodies  >1 publications with SLCO1A2 and Prostate
 Mouth Antibodies  >1 publications with SLCO1A2 and Mouth
 Embryonic Tissue Antibodies  >1 publications with SLCO1A2 and Embryonic Tissue
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