TIE2 (TEK) ELISA Kit for Mouse

TIE2: a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Protein type: Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; TK group; Tie family

Cellular Component: cell surface; microvillus; basolateral plasma membrane; integral to plasma membrane; integral to membrane; extracellular region; actin filament; intercellular junction; lipid raft; cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; basal plasma membrane; stress fiber; plasma membrane; cell junction

Molecular Function: transferase activity; protein binding; growth factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; receptor activity; kinase activity; ATP binding; protein kinase activity

Biological Process: positive regulation of cell adhesion; peptidyl-tyrosine phosphorylation; cell-matrix adhesion; heart development; protein amino acid autophosphorylation; positive regulation of cytokine secretion during immune response; protein amino acid phosphorylation; regulation of cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; cell-cell adhesion; positive regulation of focal adhesion formation; hemopoiesis; angiogenesis; vasculogenesis; Tie receptor signaling pathway; regulation of endothelial cell proliferation; response to retinoic acid; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; regulation of angiogenesis; positive regulation of peptidyl-serine phosphorylation; protein oligomerization; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; negative regulation of angiogenesis; positive regulation of protein import into nucleus; response to estrogen stimulus; endothelial cell proliferation; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis