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KLF10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS826859

MBS826859 is an antibody targeting KLF10. Also known as Anti-KLF10/11 Antibody. Reactive in Human, Mouse, Rat, Zebrafish. Host: Rabbit. Rabbit polyclonal antibody to KLF10/11 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KLF10/11, Polyclonal Antibody
Full Product Name
Anti-KLF10/11 Antibody
Product Gene Name
anti-KLF10 antibody
Product Synonym Gene Name
KLF11
Product Synonym Names
KLF10; TIEG; TIEG1; Krueppel-like factor 10; EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1; KLF11; FKLF; TIEG2; Krueppel-like factor 11; Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Zebrafish
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of KLF10/11 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
KLF10/11 peptide (MBS8223173) is used for blocking the activity of KLF10/11 antibody (MBS826859)
Molecular Weight
13,702 Da
OMIM
601878
3D Structure
ModBase 3D Structure for Q13118
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human KLF10/11. The exact sequence is proprietary.
Applications Tested/Suitable for anti-KLF10 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KLF10 antibody
WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Western Blot (WB) of anti-KLF10 antibody

Western blot analysis of KLF10/11 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.
Rabbit Anti-KLF10 Polyclonal Antibody – Cat# MBS826859

Immunohistochemistry (IHC) of anti-KLF10 antibody

Immunohistochemical analysis of KLF10/11 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-KLF10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS826859

Other Notes

Small volumes of anti-KLF10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLF10. It may not necessarily be applicable to this product.

NCBI GI #
73760403
NCBI GeneID
7071
NCBI Accession #
NP_001027453.1
UniProt Primary Accession #
Q13118
UniProt Secondary Accession #
O75411; Q503B2; A8MVH0; B2R794; L0R4P6; L0R679
UniProt Related Accession #
Q13118
GenBank Nucleotide #
NM_001032282.3
NCBI Official Full Name
Krueppel-like factor 10 isoform b
NCBI Official Synonym Full Names
Kruppel-like factor 10
NCBI Official Symbol
KLF10
NCBI Official Synonym Symbols
EGRA; TIEG; TIEG1; EGR-alpha
UniProt Protein Name
Krueppel-like factor 10
UniProt Synonym Protein Names
EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1
Protein Family
Krueppel-like factor
UniProt Gene Name
KLF10
UniProt Synonym Gene Names
TIEG; TIEG1; TGFB-inducible early growth response protein 1; TIEG-1
UniProt Entry Name
KLF10_HUMAN
NCBI Protein Information
Krueppel-like factor 10

NCBI Summary for KLF10

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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UniProt Comments for KLF10

KLF10: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: nucleus

Molecular Function: protein binding; metal ion binding; transcription factor activity

Biological Process: circadian rhythm; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of osteoclast differentiation; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; regulation of circadian rhythm; bone mineralization; negative regulation of cell proliferation; cell proliferation; cell-cell signaling; transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; skeletal development
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Research Articles on KLF10

1. KLF10 directly binds to TGF-BRII promoter in T cells, leading to enhanced gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLF10 antibody

 Reference Product  PubMed Publications
 SP1 antibody  >19 publications with KLF10 and SP1
 TGFB1 antibody  >13 publications with KLF10 and TGFB1
 SMAD7 antibody  >9 publications with KLF10 and SMAD7
 BMP2 antibody  >4 publications with KLF10 and BMP2
 PTGS1 antibody  >1 publications with KLF10 and PTGS1
 KDM5B antibody  >1 publications with KLF10 and KDM5B
 SIN3A antibody  >1 publications with KLF10 and SIN3A

Diseases associated with anti-KLF10 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >15 publications with KLF10 and Carcinoma
 Inflammation Antibodies  >12 publications with KLF10 and Inflammation
 Cardiovascular Diseases Antibodies  >10 publications with KLF10 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >7 publications with KLF10 and Disease Models, Animal
 Breast Neoplasms Antibodies  >6 publications with KLF10 and Breast Neoplasms
 Fibrosis Antibodies  >4 publications with KLF10 and Fibrosis
 Liver Diseases Antibodies  >4 publications with KLF10 and Liver Diseases
 Hypertrophy Antibodies  >3 publications with KLF10 and Hypertrophy
 Neoplasms, Experimental Antibodies  >3 publications with KLF10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >3 publications with KLF10 and Kidney Diseases

Organs/Tissues associated with anti-KLF10 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >24 publications with KLF10 and Bone
 Blood Antibodies  >21 publications with KLF10 and Blood
 Liver Antibodies  >10 publications with KLF10 and Liver
 Vascular Antibodies  >9 publications with KLF10 and Vascular
 Brain Antibodies  >9 publications with KLF10 and Brain
 Muscle Antibodies  >8 publications with KLF10 and Muscle
 Connective Tissue Antibodies  >7 publications with KLF10 and Connective Tissue
 Kidney Antibodies  >6 publications with KLF10 and Kidney
 Pancreas Antibodies  >6 publications with KLF10 and Pancreas
 Bone Marrow Antibodies  >5 publications with KLF10 and Bone Marrow
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