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CACNG3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6000690

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CACNG3, Monoclonal Antibody
Full Product Name
CACNG3 (Voltage-dependent Calcium Channel gamma-3 Subunit, Neuronal Voltage-gated Calcium Channel gamma-3 Subunit, Transmembrane AMPAR Regulatory Protein gamma-3)
Product Gene Name
anti-CACNG3 antibody
Product Synonym Names
Anti -CACNG3 (Voltage-dependent Calcium Channel gamma-3 Subunit, Neuronal Voltage-gated Calcium Channel gamma-3 Subunit, Transmembrane AMPAR Regulatory Protein gamma-3)
Immunogen Sequence
IYIEKHQQLR AKSHSEFLKK STFARLPPYR YRFRRRSSSR STEPRSRDLS PISKGFHTIP STDISMFTLS RDPSKITMGT LLNSDRDHAF LQFHNSTPK
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3E4
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CACNG3. Species Crossreactivity: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,549 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (24266874..24373737). Location: 16p12.1
OMIM
606403
3D Structure
ModBase 3D Structure for O60359
Immunogen
Partial recombinant corresponding to aa199-297 from CACNG3 (NP_006530) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-CACNG3 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-CACNG3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CACNG3 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-CACNG3 antibody

Western Blot detection against Immunogen (37kD).
Mouse Anti-CACNG3 Monoclonal Antibody – Cat# MBS6000690

Western Blot (WB) of anti-CACNG3 antibody

CACNG3 monoclonal antibody Western Blot analysis of CACNG3 expression in HeLa.
Mouse Anti-CACNG3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6000690

Western Blot (WB) of anti-CACNG3 antibody

CACNG3 monoclonal antibody Western Blot analysis of CACNG3 expression in PC-12.
Mouse Anti-CACNG3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6000690

Western Blot (WB) of anti-CACNG3 antibody

Western Blot analysis of CACNG3 expression in transfected 293T cell line by CACNG3 monoclonal antibody.|Lane 1: CACNG3 transfected lysate (35.5kD).|Lane 2: Non-transfected lysate.
Mouse Anti-CACNG3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6000690

Testing Data of anti-CACNG3 antibody

Detection limit for recombinant GST tagged CACNG3 is ~0.3ng/ml as a capture antibody.
Mouse Anti-CACNG3 Monoclonal Antibody, Testing Data – Cat# MBS6000690

Other Notes

Small volumes of anti-CACNG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNG3 purchase

MBS6000690 is an antibody targeting CACNG3. Also known as CACNG3 (Voltage-dependent Calcium Channel gamma-3 Subunit, Neuronal Voltage-gated Calcium Channel gamma-3 Subunit, Transmembrane AMPAR Regulatory Protein gamma-3). Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNG3. It may not necessarily be applicable to this product.

NCBI GI #
7230381
NCBI GeneID
10368
NCBI Accession #
AAF42975.1
UniProt Primary Accession #
O60359
UniProt Related Accession #
O60359
NCBI Official Full Name
calcium channel gamma subunit 3
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 3
NCBI Official Symbol
CACNG3
UniProt Protein Name
Voltage-dependent calcium channel gamma-3 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNG3
UniProt Synonym Gene Names
TARP gamma-3
UniProt Entry Name
CCG3_HUMAN
NCBI Protein Information
voltage-dependent calcium channel gamma-3 subunit; TARP gamma-3; voltage-gated calcium channel gamma subunit; transmembrane AMPAR regulatory protein gamma-3; neuronal voltage-gated calcium channel gamma-3 subunit

UniProt Comments for CACNG3

CACNG3: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: plasma membrane; voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity

Biological Process: synaptic transmission; calcium ion transport
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Research Articles on CACNG3

1. These results suggest that CACNG3 is the best candidate for an age-related macular degeneration risk gene within the 16p12 linkage peak.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNG3 antibody

 Reference Product  PubMed Publications
 CACNG4 antibody  >2 publications with CACNG3 and CACNG4
 CACNG1 antibody  >2 publications with CACNG3 and CACNG1
 CACNG7 antibody  >1 publications with CACNG3 and CACNG7
 CACNG6 antibody  >1 publications with CACNG3 and CACNG6

Pathways associated with anti-CACNG3 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Diseases associated with anti-CACNG3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with CACNG3 and Nervous System Diseases
 Seizures Antibodies  >3 publications with CACNG3 and Seizures
 Brain Diseases Antibodies  >3 publications with CACNG3 and Brain Diseases
 Movement Disorders Antibodies  >1 publications with CACNG3 and Movement Disorders
 Disease Models, Animal Antibodies  >1 publications with CACNG3 and Disease Models, Animal

Organs/Tissues associated with anti-CACNG3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with CACNG3 and Brain
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