ACTN2 Antibody – Rabbit Polyclonal

ACTN2: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the alpha-actinin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: sarcomere; cortical actin cytoskeleton; focal adhesion; cytoplasm; Z disc; striated muscle thin filament; filopodium

Molecular Function: protein binding, bridging; actin filament binding; protein dimerization activity; identical protein binding; LIM domain binding; protein binding; protein homodimerization activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; cytoskeletal protein binding; titin binding; calcium ion binding; actin binding; FATZ binding; thyroid hormone receptor coactivator activity

Biological Process: focal adhesion formation; regulation of membrane potential; muscle contraction; negative regulation of potassium ion transport; microspike biogenesis; positive regulation of potassium ion transport; protein homotetramerization