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QPRT Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS834632

MBS834632 is an antibody targeting QPRT. Also known as QPRT antibody. Host: Mouse. Mouse monoclonal QPRT antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
QPRT, Monoclonal Antibody
Full Product Name
QPRT antibody
Product Gene Name
Product Synonym Names
Monoclonal QPRT; Anti-QPRT; Quinolinate phosphoribosyltransferase; QPRTase;
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
3B3
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
QPRT antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
30,846 Da
OMIM
606248
3D Structure
ModBase 3D Structure for Q15274
Cross-Reactivity
Human
Immunogen
QPRT antibody was raised in mouse using a full length recombinant protein of human QPRT (NP_055113) produced in HEK293T cells, as the immunogen.

Product Categories/Family for anti-QPRT antibody

Applications Tested/Suitable for anti-QPRT antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-QPRT antibody
FC: 1:100
IF 1:50
WB: 1:2000

Flow Cytometry (FC/FACS) of anti-QPRT antibody

Flow Cytometric analysis of HEK293T cells transfected with either recombinant QPRT protein (red) or empty vector (blue) stained using QPRT antibody
Mouse Anti-QPRT Monoclonal Antibody – Cat# MBS834632

Western Blot (WB) of anti-QPRT antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant QPRT protein (Right) or empty vector (Left) detected with QPRT antibody
Mouse Anti-QPRT Monoclonal Antibody, Western Blot (WB) – Cat# MBS834632

Immunofluorescence (IF) of anti-QPRT antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant QPRT protein using QPRT antibody
Mouse Anti-QPRT Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS834632

Other Notes

Small volumes of anti-QPRT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for QPRT. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
nicotinate-nucleotide pyrophosphorylase
NCBI Official Synonym Full Names
quinolinate phosphoribosyltransferase
NCBI Official Symbol
QPRT
NCBI Official Synonym Symbols
QPRTase; HEL-S-90n
UniProt Protein Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Synonym Protein Names
Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
UniProt Gene Name
QPRT
UniProt Synonym Gene Names
QAPRTase; QPRTase
UniProt Entry Name
NADC_HUMAN
NCBI Protein Information
nicotinate-nucleotide pyrophosphorylase [carboxylating]

NCBI Summary for QPRT

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
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UniProt Comments for QPRT

QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.

Protein type: Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.19

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process; protein oligomerization
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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