SPK1 Antibody – Rabbit Polyclonal

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

SPHK1: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Interacts with ACY1. Binds to calmodulin. Interacts with SPHKAP. Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - sphingolipid; EC 2.7.1.91; Kinase, lipid

Cellular Component: synaptic vesicle; neuron projection; membrane; axon; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: D-erythro-sphingosine kinase activity; transferase activity; calmodulin binding; DNA binding; protein phosphatase 2A binding; sphinganine kinase activity; magnesium ion binding; nucleotide binding; kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: blood vessel development; metabolic process; cyclooxygenase pathway; calcium-mediated signaling; positive regulation of NF-kappaB import into nucleus; sphingosine metabolic process; positive regulation of mitotic cell cycle; lipid phosphorylation; positive regulation of cell growth; positive regulation of neurotransmitter secretion; activation of NF-kappaB transcription factor; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; positive regulation of protein ubiquitination; regulation of interleukin-1 beta production; positive regulation of cell proliferation; protein kinase C activation; positive regulation of protein amino acid phosphorylation; positive regulation of smooth muscle contraction; brain development; inflammatory response; phosphorylation; negative regulation of apoptosis; positive regulation of cell migration