RNASEH1 Antibody – Rabbit Polyclonal

This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2. [provided by RefSeq, Sep 2014]

RNASEH1: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids. Belongs to the RNase H family.

Protein type: Mitochondrial; RNA-binding; Ribonuclease; EC 3.1.26.4

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: mitochondrion; nucleus

Molecular Function: protein homodimerization activity; nucleic acid binding; RNA binding; magnesium ion binding; ribonuclease H activity; ribonuclease activity

Biological Process: RNA catabolic process; mitochondrial DNA replication; termination of RNA polymerase II transcription

Disease: Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 2