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AMG-517

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400460

AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC50 of 0.9nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when administered intrathecally at a dose of 165ug. It (150 and 300ug/kg)… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
AMG-517, Biochemical
Full Product Name
AMG-517
Product Gene Name
AMG-517 biochemical
Product Synonym Names
N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1, 3-benzothiazol-2-yl]acetamide; N-(4-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)benzo[d]thiazol-2-yl)acetamide
Form/Format
Off White solid
Purity/Purification
>98%
Specificity
An antagonist of transient receptor potential vanilloid 1 (TRPV1)
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
430.4
Solubilities
~14mg/ml in DMSO; ~3mg/ml in Ethanol
Molecular Formula
C??H??F?N?O?S
InChi
InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21; 22)23/h2-10H; 1H3; (H; 26; 27; 28)
InChi Key
YUTIXVXZQIQWGY-UHFFFAOYSA-N
SMILES
CC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F
CAS Number
659730-32-2
MDL Number
MFCD14584859
PubChem CID
16007367

Product Categories/Family for AMG-517 biochemical

Web Categories; Biochemicals; Biochemicals (A-Z); Neuroscience; Neuroprotective agents

Structure of AMG-517 biochemical

AMG-517 Biochemical – Cat# MBS8400460

Product References and Citations for AMG-517 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/16007367

Other Notes

Small volumes of AMG-517 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMG-517 purchase

MBS8400460 is a biochemical targeting AMG-517.
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