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CHCHD3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9603482

Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHCHD3, Polyclonal Antibody
Full Product Name
CHCHD3 Antibody
Product Gene Name
anti-CHCHD3 antibody
Product Synonym Names
CHCH3_HUMAN; CHCHD 3; Chchd3; Coiled coil helix coiled coil helix domain containing 3; Coiled coil helix coiled coil helix domain containing protein 3 mitochondrial; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3; FLJ20420; MINOS3; mitochondrial; Mitochondrial inner membrane organizing system 3; PPP1R22; Protein phosphatase 1 regulatory subunit 22
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
CHCHD3 antibody detects endogenous levels of CHCHD3.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
CHCHD3 peptide (MBS9620959) is used for blocking the activity of CHCHD3 antibody (MBS9603482)
Molecular Weight
Observed: 26 kDa
Predicted: 27 kDa
3D Structure
ModBase 3D Structure for Q9NX63
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human CHCHD3.
Subcellular Location
Mitochondrion Inner Membrane. Cytoplasm. Nucleus.
Tissue Specificity
Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (92%), Bovine (92%), Horse (92%), Sheep (92%), Rabbit (100%), Dog (92%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CHCHD3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHCHD3 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-CHCHD3 antibody

Western blot analysis of extracts of A431 cells, using CHCHD3 antibody.
Rabbit Anti-CHCHD3 Polyclonal Antibody – Cat# MBS9603482

Immunohistochemistry (IHC) of anti-CHCHD3 antibody

MBS9603482 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-CHCHD3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9603482

Other Notes

Small volumes of anti-CHCHD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHCHD3 purchase

MBS9603482 is an antibody targeting CHCHD3. Also known as CHCHD3 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHCHD3. It may not necessarily be applicable to this product.

NCBI GI #
953768340
NCBI GeneID
54927
NCBI Accession #
NP_001304106.1
UniProt Primary Accession #
Q9NX63
UniProt Related Accession #
Q9NX63
GenBank Nucleotide #
NM_001317177.1
NCBI Official Full Name
MICOS complex subunit MIC19 isoform 1
NCBI Official Synonym Full Names
coiled-coil-helix-coiled-coil-helix domain containing 3
NCBI Official Symbol
CHCHD3
NCBI Official Synonym Symbols
Mic19; MINOS3; PPP1R22
UniProt Protein Name
MICOS complex subunit MIC19
UniProt Synonym Protein Names
Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
UniProt Gene Name
CHCHD3
UniProt Synonym Gene Names
MIC19; MINOS3
NCBI Protein Information
MICOS complex subunit MIC19

NCBI Summary for CHCHD3

The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
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UniProt Comments for CHCHD3

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).
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Research Articles on CHCHD3

1. Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CHCHD3 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with CHCHD3 and Brain Diseases
 Breast Neoplasms Antibodies  >1 publications with CHCHD3 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >1 publications with CHCHD3 and Pancreatic Neoplasms
 Edema Antibodies  >1 publications with CHCHD3 and Edema
 Fatty Liver Antibodies  >1 publications with CHCHD3 and Fatty Liver

Organs/Tissues associated with anti-CHCHD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >8 publications with CHCHD3 and Muscle
 Brain Antibodies  >3 publications with CHCHD3 and Brain
 Liver Antibodies  >2 publications with CHCHD3 and Liver
 Vascular Antibodies  >2 publications with CHCHD3 and Vascular
 Blood Antibodies  >1 publications with CHCHD3 and Blood
 Mammary Gland Antibodies  >1 publications with CHCHD3 and Mammary Gland
 Heart Antibodies  >1 publications with CHCHD3 and Heart
 Bone Antibodies  >1 publications with CHCHD3 and Bone
 Eye Antibodies  >1 publications with CHCHD3 and Eye
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