Rabbit Anti-CTSD Polyclonal Antibody – Cat# MBS840224

Cathepsin D (CTSD) Antibody – Rabbit Polyclonal

Name: CTSD Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840224
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840224

Background: Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cathepsin D (CTSD), Polyclonal Antibody

Full Product Name

Cathepsin D Antibody

Product Gene Name

anti-CTSD antibody

Product Synonym Names

CTSD; CLN10; CPSD; MGC2311

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit anti-cathepsin D polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purity/Purification

Affinity purified

Specificity

The purified antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D.

Preparation and Storage

Store at -20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/ defrost cycles.

OMIM

116840

Immunogen

Synthetic peptide surrounding amino acid 140 of mouse cathepsin D

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-CTSD antibody

Western Blot (WB)

Application Notes for anti-CTSD antibody

The antibody can be used for Western Blot analysis(0.5-4 ug/mL). It can also be used in immunoprecipitation. However, the optimal conditions should be determined individually.

Other Notes

Small volumes of anti-CTSD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSD purchase

MBS840224 is an antibody targeting CTSD. Also known as Cathepsin D Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSD. It may not necessarily be applicable to this product.

NCBI GI #

4503143

NCBI GeneID

1509

NCBI Accession #

NP_001900.1

UniProt Secondary Accession #

Q6IB57

UniProt Related Accession #

P07339

GenBank Nucleotide #

NM_001909.4

NCBI Official Full Name

cathepsin D preproprotein

NCBI Official Synonym Full Names

cathepsin D

NCBI Official Symbol

CTSD

NCBI Official Synonym Symbols

CPSD; CLN10; HEL-S-130P

UniProt Protein Name

Cathepsin D

Protein Family

Aspartic-type endopeptidase

UniProt Gene Name

CTSD

UniProt Synonym Gene Names

CPSD

UniProt Entry Name

CATD_HUMAN

NCBI Protein Information

cathepsin D

NCBI Summary for CTSD

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

UniProt Comments for CTSD

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: EC 3.4.23.5; Protease; Motility/polarity/chemotaxis; Autophagy

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; lysosome; extracellular region; melanosome

Molecular Function: protein binding; aspartic-type endopeptidase activity

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10

Research Articles on CTSD

1. These results suggest that decreased expression of cathepsin D in the peripheral monocytes is a potential signature of Alzheimer disease,and that this decreased expression is involved in Abeta degradation and Alzheimer disease pathogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTSD antibody

Reference Product	PubMed Publications
CTSB antibody	>33 publications with CTSD and CTSB
TP53 antibody	>5 publications with CTSD and TP53
CTSS antibody	>4 publications with CTSD and CTSS
CTSA antibody	>2 publications with CTSD and CTSA
BID antibody	>1 publications with CTSD and BID
ESR1 antibody	>1 publications with CTSD and ESR1

Diseases associated with anti-CTSD antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>63 publications with CTSD and Nervous System Diseases
Disease Models, Animal Antibodies	>23 publications with CTSD and Disease Models, Animal
Breast Neoplasms Antibodies	>18 publications with CTSD and Breast Neoplasms
Inflammation Antibodies	>17 publications with CTSD and Inflammation
Necrosis Antibodies	>8 publications with CTSD and Necrosis
Neoplasm Invasiveness Antibodies	>8 publications with CTSD and Neoplasm Invasiveness
Cardiovascular Diseases Antibodies	>7 publications with CTSD and Cardiovascular Diseases
Fibrosis Antibodies	>6 publications with CTSD and Fibrosis
Liver Neoplasms Antibodies	>6 publications with CTSD and Liver Neoplasms
Seizures Antibodies	>5 publications with CTSD and Seizures

Organs/Tissues associated with anti-CTSD antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>43 publications with CTSD and Blood
Brain Antibodies	>40 publications with CTSD and Brain
Liver Antibodies	>25 publications with CTSD and Liver
Muscle Antibodies	>21 publications with CTSD and Muscle
Lung Antibodies	>15 publications with CTSD and Lung
Kidney Antibodies	>12 publications with CTSD and Kidney
Eye Antibodies	>10 publications with CTSD and Eye
Vascular Antibodies	>9 publications with CTSD and Vascular
Bone Antibodies	>9 publications with CTSD and Bone
Skin Antibodies	>6 publications with CTSD and Skin