Rabbit Anti-HRK Polyclonal Antibody – Cat# MBS840389

HRK Antibody – Rabbit Polyclonal

Name: HRK Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840389
Price: 420 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840389

Background: Members of the Bcl-2 family of proteins interact to regulate programmed cell death, or apoptosis. Various homodimers and heterodimers formed by proteins in this family can either promote or inhibit apoptosis. Bcl-2 blocks cell death following a… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Hrk, Polyclonal Antibody

Full Product Name

Hrk Antibody

Product Gene Name

anti-Hrk antibody

Product Synonym Names

BID3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

100 ug (0.5 mg/ml) antigen affinity purified rabbit anti-human Hrk polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

9,884 Da

OMIM

603447

Immunogen

Synthetic peptide corresponding to residues surrounding amino acids 50 of human HRK

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-Hrk antibody

Western Blot (WB)

Application Notes for anti-Hrk antibody

Western blot analysis (1 ug/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects human Hrk fused with green fluorescent protein in crude extracts of E. coli transfected with Hrk-GFP.

Other Notes

Small volumes of anti-Hrk antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hrk purchase

MBS840389 is an antibody targeting Hrk. Also known as Hrk Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Hrk. It may not necessarily be applicable to this product.

NCBI GI #

1923235

NCBI GeneID

8739

NCBI Accession #

AAC34931

UniProt Related Accession #

O00198

NCBI Official Full Name

activator of apoptosis Hrk

NCBI Official Synonym Full Names

harakiri, BCL2 interacting protein

NCBI Official Symbol

HRK

NCBI Official Synonym Symbols

DP5; HARAKIRI

UniProt Protein Name

Activator of apoptosis harakiri

UniProt Synonym Protein Names

BH3-interacting domain-containing protein 3; Neuronal death protein DP5

Protein Family

Activator of apoptosis harakiri

UniProt Gene Name

HRK

UniProt Synonym Gene Names

BID3

UniProt Entry Name

HRK_HUMAN

NCBI Protein Information

activator of apoptosis harakiri

NCBI Summary for Hrk

This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

UniProt Comments for Hrk

HRK: Promotes apoptosis.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 12q24.22

Cellular Component: mitochondrion; integral to membrane

Molecular Function: protein binding

Biological Process: apoptosis; positive regulation of protein homooligomerization; positive regulation of apoptosis

Research Articles on Hrk

1. our findings suggest that induction of the BH3-only protein Hrk is a critical step in 2-ME activation of the JNK-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Hrk antibody

Reference Product	PubMed Publications
JUN antibody	>32 publications with Hrk and JUN
BCL2L1 antibody	>15 publications with Hrk and BCL2L1
BIK antibody	>13 publications with Hrk and BIK
MCL1 antibody	>4 publications with Hrk and MCL1
ATF2 antibody	>3 publications with Hrk and ATF2
STAT1 antibody	>2 publications with Hrk and STAT1
ATF3 antibody	>2 publications with Hrk and ATF3

Pathways associated with anti-Hrk antibody

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Modulation And Signaling Pathway antibodies	Apoptosis Modulation And Signaling Pathway Diagram

Diseases associated with anti-Hrk antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>21 publications with Hrk and Nervous System Diseases
Brain Diseases Antibodies	>9 publications with Hrk and Brain Diseases
Inflammation Antibodies	>6 publications with Hrk and Inflammation
Cardiovascular Diseases Antibodies	>5 publications with Hrk and Cardiovascular Diseases
Breast Neoplasms Antibodies	>5 publications with Hrk and Breast Neoplasms
Necrosis Antibodies	>5 publications with Hrk and Necrosis
Disease Models, Animal Antibodies	>3 publications with Hrk and Disease Models, Animal
Abnormalities, Drug-Induced Antibodies	>2 publications with Hrk and Abnormalities, Drug-Induced
Lung Neoplasms Antibodies	>2 publications with Hrk and Lung Neoplasms
Seizures Antibodies	>2 publications with Hrk and Seizures

Organs/Tissues associated with anti-Hrk antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>22 publications with Hrk and Brain
Lymph Node Antibodies	>2 publications with Hrk and Lymph Node
Testis Antibodies	>1 publications with Hrk and Testis
Thyroid Antibodies	>1 publications with Hrk and Thyroid