Rabbit Anti-FIS1 Polyclonal Antibody – Cat# MBS840418

FIS1 Antibody – Rabbit Polyclonal

Name: FIS1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840418
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840418

Background: hFis1 is a novel molecule that was discovered as part of the mammalian fission machinery. Fis 1 has been smuggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Fis1, Polyclonal Antibody

Full Product Name

Fis1 Antibody

Product Gene Name

anti-Fis1 antibody

Product Synonym Names

hFis1; TTC11; H_NH0132A01.6; CGI-135

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

16,938 Da

OMIM

609003

3D Structure

ModBase 3D Structure for Q9Y3D6

Immunogen

Synthetic peptide surrounding amino acid 143 of human Fis1

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-Fis1 antibody

Western Blot (WB)

Application Notes for anti-Fis1 antibody

Western blotting (1-4 ug/ml). Per research's feedback, the antibody can also be used in immunofluorescence. However, the optimal concentrations should be determined individually. The antibody recognizes Fis1 of human, mouse, and rat origins.

Other Notes

Small volumes of anti-Fis1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Fis1 purchase

MBS840418 is an antibody targeting Fis1. Also known as Fis1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Fis1. It may not necessarily be applicable to this product.

NCBI GI #

151108473

NCBI GeneID

51024

NCBI Accession #

NP_057152.2

UniProt Primary Accession #

Q9Y3D6

UniProt Secondary Accession #

Q9BTP3

UniProt Related Accession #

Q9Y3D6

GenBank Nucleotide #

NM_016068.2

NCBI Official Full Name

mitochondrial fission 1 protein

NCBI Official Synonym Full Names

fission, mitochondrial 1

NCBI Official Symbol

FIS1

NCBI Official Synonym Symbols

TTC11; CGI-135

UniProt Protein Name

Mitochondrial fission 1 protein

UniProt Synonym Protein Names

FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11

Protein Family

Mitochondria fission 1 protein

UniProt Gene Name

FIS1

UniProt Synonym Gene Names

TTC11; hFis1; TPR repeat protein 11

UniProt Entry Name

FIS1_HUMAN

NCBI Protein Information

mitochondrial fission 1 protein

NCBI Summary for Fis1

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

UniProt Comments for Fis1

FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family.

Protein type: Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to peroxisomal membrane; protein complex; membrane; mitochondrion; peroxisome; integral to mitochondrial outer membrane

Molecular Function: protein binding; receptor binding

Biological Process: peroxisome fission; mitochondrial fission; elevation of cytosolic calcium ion concentration; release of cytochrome c from mitochondria; mitochondrial fusion; reduction of endoplasmic reticulum calcium ion concentration; mitochondrion degradation; positive regulation of caspase activity; mitochondrial fragmentation during apoptosis; protein targeting to mitochondrion; protein homooligomerization; elevation of mitochondrial calcium ion concentration

Research Articles on Fis1

1. Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Fis1 antibody

Reference Product	PubMed Publications
MFN1 antibody	>51 publications with Fis1 and MFN1
MFN2 antibody	>50 publications with Fis1 and MFN2
DNM1L antibody	>41 publications with Fis1 and DNM1L
PEX11A antibody	>6 publications with Fis1 and PEX11A
BCL2L1 antibody	>4 publications with Fis1 and BCL2L1
TOMM40 antibody	>3 publications with Fis1 and TOMM40
PEX11G antibody	>1 publications with Fis1 and PEX11G
MARCH5 antibody	>1 publications with Fis1 and MARCH5

Diseases associated with anti-Fis1 antibody

Disease Name	Pubmed Publications
Death Antibodies	>58 publications with Fis1 and Death
Nervous System Diseases Antibodies	>31 publications with Fis1 and Nervous System Diseases
Atrophy Antibodies	>23 publications with Fis1 and Atrophy
Heart Diseases Antibodies	>8 publications with Fis1 and Heart Diseases
Carcinoma Antibodies	>5 publications with Fis1 and Carcinoma
Movement Disorders Antibodies	>5 publications with Fis1 and Movement Disorders
Inflammation Antibodies	>5 publications with Fis1 and Inflammation
Diabetes Mellitus Antibodies	>4 publications with Fis1 and Diabetes Mellitus
Heart Failure Antibodies	>4 publications with Fis1 and Heart Failure
Necrosis Antibodies	>4 publications with Fis1 and Necrosis

Organs/Tissues associated with anti-Fis1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>30 publications with Fis1 and Brain
Muscle Antibodies	>29 publications with Fis1 and Muscle
Heart Antibodies	>17 publications with Fis1 and Heart
Blood Antibodies	>9 publications with Fis1 and Blood
Vascular Antibodies	>9 publications with Fis1 and Vascular
Lung Antibodies	>7 publications with Fis1 and Lung
Liver Antibodies	>6 publications with Fis1 and Liver
Pancreas Antibodies	>4 publications with Fis1 and Pancreas
Adipose Tissue Antibodies	>4 publications with Fis1 and Adipose Tissue
Prostate Antibodies	>3 publications with Fis1 and Prostate