Rabbit Anti-PRMT-5 Polyclonal Antibody – Cat# MBS840578

PRMT-5 Antibody – Rabbit Polyclonal

Name: PRMT-5 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840578
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840578

Background: Protein arginine N-methyltransferase 5 (PRMT-5) is a member of the PRMT family that localizes to the cytoplasm in many types of tissues. At least three types of PRMT enzymes have been identified that shows essential regulatory functions by… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PRMT-5, Polyclonal Antibody

Full Product Name

PRMT-5 Antibody

Product Gene Name

anti-PRMT-5 antibody

Product Synonym Names

PRMT5; Protein Arginine Methyltransferase 5; HRMT1L5; HMT1 hnRNP Methyltransferase-Like 5; SKB1; Shk1 Kinase-Binding protein; IBP72; 72 kDa ICln-binding protein; JBP1; Jak-binding protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit anti-PRMT-5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

83,292 Da

Immunogen

Synthetic peptide surrounding amino acid 51 of rat PRMT-5

Positive Control

Jurkat cell lysate

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-PRMT-5 antibody

Western Blot (WB)

Application Notes for anti-PRMT-5 antibody

Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.

Other Notes

Small volumes of anti-PRMT-5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRMT-5 purchase

MBS840578 is an antibody targeting PRMT-5. Also known as PRMT-5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRMT-5. It may not necessarily be applicable to this product.

NCBI GI #

17552468

NCBI GeneID

175717

NCBI Accession #

NP_498112.1

UniProt Secondary Accession #

Q8T8N5

UniProt Related Accession #

P46580

GenBank Nucleotide #

NM_065711.6

NCBI Official Full Name

PRMT-5

NCBI Official Symbol

prmt-5

UniProt Protein Name

Protein arginine N-methyltransferase 5

UniProt Gene Name

prmt-5

UniProt Entry Name

ANM5_CAEEL

NCBI Protein Information

PRMT-5

UniProt Comments for PRMT-5

Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1 (PubMed:19521535, PubMed:23866019, PubMed:22143770). Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group (PubMed:23866019). Plays a role in the negative regulation of DNA damage-induced apoptosis (PubMed:19521535). By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535).

Research Articles on PRMT-5

1. data confirm that MEP50 plays a key role in substrate recognition and activates PRMT5 activity by increasing its affinity for protein substrates.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRMT-5 antibody

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