Rabbit Anti-RbBP5 Polyclonal Antibody – Cat# MBS840886

RbBP5 Antibody – Rabbit Polyclonal

Name: RbBP5 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840886
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840886

Background: Retinoblastoma binding protein 5 (RbBP5) belongs to a highly conserved subfamily of WD-repeat proteins and it is also a subunit of a human Set1-like histone methyltransferase (HMT) complex. The encoded RbBP 5protein interacts preferentially with… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

RbBP5, Polyclonal Antibody

Full Product Name

RbBP5 Antibody

Product Gene Name

anti-RbBP5 antibody

Product Synonym Names

RbBP5; Retinoblastoma binding protein 5; RBQ3; Retinoblastoma binding protein RBQ3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

40,764 Da

Immunogen

Synthetic peptide corresponding to residues surrounding amino acids 504 of mouse RbBP5

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-RbBP5 antibody

Western Blot (WB)

Application Notes for anti-RbBP5 antibody

Western blotting (0.5-4 mug/ml). However, the optimal concentrations should be determined individually. Jurkat cell can be used as a positive control. Reacts with human/mouse/rat. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-RbBP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RbBP5 purchase

MBS840886 is an antibody targeting RbBP5. Also known as RbBP5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RbBP5. It may not necessarily be applicable to this product.

NCBI GI #

164450487

NCBI GeneID

213464

NCBI Accession #

NP_766105

UniProt Secondary Accession #

Q3TBL4; Q3U3G1; Q6PAP0; Q6PFC2

UniProt Related Accession #

Q8BX09

GenBank Nucleotide #

NM_172517.2

NCBI Official Full Name

retinoblastoma-binding protein 5

NCBI Official Synonym Full Names

retinoblastoma binding protein 5

NCBI Official Symbol

Rbbp5

NCBI Official Synonym Symbols

C330016J05; 4933411J24Rik

UniProt Protein Name

Retinoblastoma-binding protein 5

Protein Family

Retinoblastoma-binding protein

UniProt Gene Name

Rbbp5

UniProt Synonym Gene Names

RBBP-5

UniProt Entry Name

RBBP5_MOUSE

NCBI Protein Information

retinoblastoma-binding protein 5

UniProt Comments for RbBP5

RBBP5: As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A. Ubiquitously expressed. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Cellular Component: histone methyltransferase complex; nucleolus; nucleus

Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); methylated histone residue binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to estrogen stimulus; histone H3-K4 methylation; chromatin modification; response to DNA damage stimulus

Research Articles on RbBP5

1. a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2) enzyme methylation rates

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.