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Cathepsin K (CTSK) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS841102

Background: Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease… More details

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Product Overview

Product Name
Cathepsin K (Ctsk), Polyclonal Antibody
Full Product Name
Cathepsin K Antibody
Product Gene Name
anti-Ctsk antibody
Product Synonym Names
CTSK; CTSO2; CTSO; CTSO1; PKND; CTS02; PYCD; MGC23107; EC 3.4.22.38
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Chicken, Rabbit, Pig
Form/Format
100 ug (0.5 mg/ml) protein A purified rabbit anti-cathepsin K polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
36,791 Da
Immunogen
Synthetic peptide surrounding amino acid 321 of rat cathepsin K
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-Ctsk antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-Ctsk antibody
Western blotting (0.5-4 ug/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. The antibody detects proform (43 kDa) and the mature form (29 kDa) of cathepsin K.

Testing Data of anti-Ctsk antibody

Rabbit Anti-CTSK Polyclonal Antibody – Cat# MBS841102

Other Notes

Small volumes of anti-Ctsk antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ctsk purchase

MBS841102 is an antibody targeting Ctsk. Also known as Cathepsin K Antibody. Reactive in Human, Mouse, Rat, Chicken, Rabbit, Pig. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Ctsk. It may not necessarily be applicable to this product.

NCBI GI #
13928758
NCBI GeneID
29175
NCBI Accession #
NP_113748
UniProt Related Accession #
O35186
GenBank Nucleotide #
NM_031560.2
NCBI Official Full Name
cathepsin K
NCBI Official Synonym Full Names
cathepsin K
NCBI Official Symbol
Ctsk
UniProt Protein Name
Cathepsin K
Protein Family
Cathepsin
UniProt Gene Name
Ctsk
UniProt Entry Name
CATK_RAT
NCBI Protein Information
cathepsin K

NCBI Summary for Ctsk

putative protease; human homolog displays endoprotease activity and is associated with pycnodysostosis when mutated [RGD, Feb 2006]

UniProt Comments for Ctsk

CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.

Protein type: Protease; EC 3.4.22.38

Cellular Component: extracellular space; lysosome; cytoplasm

Molecular Function: collagen binding; proteoglycan binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: collagen catabolic process; intramembranous ossification; proteolysis involved in cellular protein catabolic process; proteolysis; bone resorption
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Research Articles on Ctsk

1. Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Ctsk antibody

 Reference Product  PubMed Publications
 Tnfsf11 antibody  >134 publications with Ctsk and Tnfsf11
 Mitf antibody  >22 publications with Ctsk and Mitf
 Mmp13 antibody  >9 publications with Ctsk and Mmp13
 Bmp2 antibody  >6 publications with Ctsk and Bmp2
 Mmp7 antibody  >4 publications with Ctsk and Mmp7
 Tlr9 antibody  >3 publications with Ctsk and Tlr9
 Col18a1 antibody  >1 publications with Ctsk and Col18a1
 Tlr7 antibody  >1 publications with Ctsk and Tlr7

Pathways associated with anti-Ctsk antibody

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Osteoclast Pathway antibodies  Osteoclast Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with anti-Ctsk antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >62 publications with Ctsk and Necrosis
 Disease Models, Animal Antibodies  >58 publications with Ctsk and Disease Models, Animal
 Pycnodysostosis Antibodies  >54 publications with Ctsk and Pycnodysostosis
 Inflammation Antibodies  >49 publications with Ctsk and Inflammation
 Cardiovascular Diseases Antibodies  >32 publications with Ctsk and Cardiovascular Diseases
 Atherosclerosis Antibodies  >22 publications with Ctsk and Atherosclerosis
 Lung Diseases Antibodies  >22 publications with Ctsk and Lung Diseases
 Nervous System Diseases Antibodies  >21 publications with Ctsk and Nervous System Diseases
 Fibrosis Antibodies  >16 publications with Ctsk and Fibrosis
 Congenital Abnormalities Antibodies  >15 publications with Ctsk and Congenital Abnormalities

Organs/Tissues associated with anti-Ctsk antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >112 publications with Ctsk and Connective Tissue
 Lung Antibodies  >41 publications with Ctsk and Lung
 Artery Antibodies  >17 publications with Ctsk and Artery
 Kidney Antibodies  >16 publications with Ctsk and Kidney
 Heart Antibodies  >16 publications with Ctsk and Heart
 Brain Antibodies  >16 publications with Ctsk and Brain
 Spleen Antibodies  >14 publications with Ctsk and Spleen
 Prostate Antibodies  >13 publications with Ctsk and Prostate
 Embryonic Tissue Antibodies  >13 publications with Ctsk and Embryonic Tissue
 Ovary Antibodies  >8 publications with Ctsk and Ovary
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