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EZH2 Inhibitor, EPZ005687

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842404

Background: A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
EZH2 Inhibitor, EPZ005687, Biochemical
Full Product Name
EZH2 Inhibitor, EPZ005687
Product Synonym Names
1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
Form/Format
Appearance: White solid
Purity/Purification
>=99%HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
539.67
CAS Number
1396772-26-1
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
No
PubChem CID
60160561
Solubility/Reconstitution Instructions
DMSO
SMILES
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
InChi
InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
InChi Key
ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for EZH2 Inhibitor, EPZ005687 biochemical

Enzyme Inhibitors; Methyltransferase Inhibitors and Biochemicals; Enzyme Inhibitors; Methyltransferase Inhibitors and Home; ; Epigenetics; Writer Enzymes; Protein Lysine Methyltransferases (PKMTs); PKMT Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of EZH2 Inhibitor, EPZ005687 biochemical

EZH2 Inhibitor, EPZ005687 Biochemical – Cat# MBS842404

Other Notes

Small volumes of EZH2 Inhibitor, EPZ005687 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EZH2 Inhibitor, EPZ005687 purchase

MBS842404 is a biochemical targeting EZH2 Inhibitor, EPZ005687.
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