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GSK-2118436 mesylate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842715

Background: GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC?? of 0.8 nM, compared to wild type B-Raf and c-Raf with IC??s of 3.2 nM and 5.0… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK-2118436 mesylate, Biochemical
Full Product Name
GSK-2118436 mesylate
Product Synonym Names
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; methanesulfonic acid; Dabrafenib Mesylate
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
615.67
CAS Number
1195768-06-9
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Y
PubChem CID
44516822
Solubility/Reconstitution Instructions
DMSO
SMILES
O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O.CS(O)(=O)=O
InChi
InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)
InChi Key
YKGMKSIHIVVYKY-UHFFFAOYSA-N
Handling
Protect from air and moisture

Product Categories/Family for GSK-2118436 mesylate biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Raf Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Raf Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzyme Inhibitors (A-Z) Signali

Structure of GSK-2118436 mesylate biochemical

GSK-2118436 mesylate Biochemical – Cat# MBS842715

Other Notes

Small volumes of GSK-2118436 mesylate biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-2118436 mesylate purchase

MBS842715 is a biochemical targeting GSK-2118436 mesylate.
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