TNFRSF4/OX40/CD134 (TNFRSF4) Active Protein

Name: TNFRSF4 Active Protein; TNFRSF4/OX40/CD134; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844122
Price: 360 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844122

Background: Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40 / TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TNFRSF4/OX40/CD134, Active Protein

Full Product Name

Human CellExp TNFRSF4 / OX40 / CD134, human recombinant

Product Gene Name

TNFRSF4 active protein

Product Synonym Names

TNFRSF4; OX40; CD134; OX40L receptor; ACT35; TXGP1L

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=92%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with 6× his tag at the C-terminus, and has a calculated MW of 21 kDa. The predicted N-terminus is Leu 29. DTT-reduced Protein migrates as 35-48 kDa in SDS-PAGE due to glycosylation.

OMIM

600315

3D Structure

ModBase 3D Structure for P43489

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF4 / OX40 / CD134 at 2 mug/ml (100 mul/well) can bind human TNFSF4 Fc Chimera. The EC50 of human TNFSF4 Fc Chimera is 30 ng/mL.

Results

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TNFRSF4 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors &

Applications Tested/Suitable for TNFRSF4 active protein

SDS-PAGE

Other Notes

Small volumes of TNFRSF4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF4 purchase

MBS844122 is an active protein targeting TNFRSF4. Also known as Human CellExp TNFRSF4 / OX40 / CD134, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF4. It may not necessarily be applicable to this product.

NCBI GI #

4507579

NCBI GeneID

7293

NCBI Accession #

NP_003318.1

UniProt Primary Accession #

P43489

UniProt Secondary Accession #

Q13663; Q2M312; Q5T7M0

UniProt Related Accession #

P43489

GenBank Nucleotide #

NM_003327.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 4

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 4

NCBI Official Symbol

TNFRSF4

NCBI Official Synonym Symbols

OX40; ACT35; CD134; IMD16; TXGP1L

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 4

UniProt Synonym Protein Names

ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFRSF4

UniProt Synonym Gene Names

TXGP1L

UniProt Entry Name

TNR4_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 4

NCBI Summary for TNFRSF4

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

UniProt Comments for TNFRSF4

TNFRSF4: Receptor for TNFSF4/OX40L/GP34.

Protein type: Receptor, misc.; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: regulation of apoptosis; T cell proliferation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; regulation of protein kinase activity; inflammatory response

Disease: Immunodeficiency 16

Research Articles on TNFRSF4

1. High expression of OX40 is associated with type 1 diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFRSF4 active protein

Reference Product	PubMed Publications
TNFSF4 active protein	>194 publications with TNFRSF4 and TNFSF4
TNFRSF9 active protein	>41 publications with TNFRSF4 and TNFRSF9
IL2RA active protein	>18 publications with TNFRSF4 and IL2RA
IL2RB active protein	>4 publications with TNFRSF4 and IL2RB
TSLP active protein	>3 publications with TNFRSF4 and TSLP
IL2RG active protein	>3 publications with TNFRSF4 and IL2RG
IL4 active protein	>2 publications with TNFRSF4 and IL4
TRAF1 active protein	>2 publications with TNFRSF4 and TRAF1
TRAF5 active protein	>2 publications with TNFRSF4 and TRAF5

Pathways associated with TNFRSF4 active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
TNFR2 Non-canonical NF-kB Pathway antibodies	TNFR2 Non-canonical NF-kB Pathway Diagram
TNFs Bind Their Physiological Receptors Pathway antibodies	TNFs Bind Their Physiological Receptors Pathway Diagram

Diseases associated with TNFRSF4 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>297 publications with TNFRSF4 and Necrosis
Immune System Diseases Antibodies	>126 publications with TNFRSF4 and Immune System Diseases
Autoimmune Diseases Antibodies	>61 publications with TNFRSF4 and Autoimmune Diseases
Disease Models, Animal Antibodies	>60 publications with TNFRSF4 and Disease Models, Animal
Inflammation Antibodies	>51 publications with TNFRSF4 and Inflammation
Hypersensitivity Antibodies	>26 publications with TNFRSF4 and Hypersensitivity
Lung Diseases Antibodies	>24 publications with TNFRSF4 and Lung Diseases
Nervous System Diseases Antibodies	>24 publications with TNFRSF4 and Nervous System Diseases
Neoplasms, Experimental Antibodies	>23 publications with TNFRSF4 and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>22 publications with TNFRSF4 and Cardiovascular Diseases

Organs/Tissues associated with TNFRSF4 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>353 publications with TNFRSF4 and Blood
Lymph Node Antibodies	>48 publications with TNFRSF4 and Lymph Node
Lung Antibodies	>24 publications with TNFRSF4 and Lung
Skin Antibodies	>23 publications with TNFRSF4 and Skin
Intestine Antibodies	>8 publications with TNFRSF4 and Intestine
Kidney Antibodies	>6 publications with TNFRSF4 and Kidney
Stomach Antibodies	>1 publications with TNFRSF4 and Stomach