Fc Gamma RIIIB/Cd16b (FCGR3B) Active Protein

Name: FCGR3B Active Protein; Fc Gamma RIIIB/Cd16b; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844284
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844284

Background: CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcgammaRIIIa (CD16a) and FcgammaRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Fc gamma RIIIB/CD16b (FCGR3B), Active Protein

Full Product Name

Human CellExp Fc gamma RIIIB / CD16b, human recombinant

Product Gene Name

FCGR3B active protein

Product Synonym Names

FCGR3B; CD16B; FCG3B; FCGR3; FCG3; IGFR3

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 21.7 kDa. The predicted N-terminus is Gly 17. DTT-reduced Protein migrates as 38-50 kDa due to glycosylation.

OMIM

610665

3D Structure

ModBase 3D Structure for O75015

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its ability to bind human IgG with an estimated KD < 150 nM.

Results

Measured by its ability to bind human IgG with an estimated KD < 150 nM.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for FCGR3B active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors &

Applications Tested/Suitable for FCGR3B active protein

SDS-PAGE

Other Notes

Small volumes of FCGR3B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR3B purchase

MBS844284 is an active protein targeting FCGR3B. Also known as Human CellExp Fc gamma RIIIB / CD16b, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR3B. It may not necessarily be applicable to this product.

NCBI GI #

132814489

NCBI GeneID

2215

NCBI Accession #

NP_000561.3

UniProt Primary Accession #

O75015

UniProt Related Accession #

O75015

GenBank Nucleotide #

NM_000570.4

NCBI Official Full Name

low affinity immunoglobulin gamma Fc region receptor III-B isoform 2

NCBI Official Synonym Full Names

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

NCBI Official Symbol

FCGR3B

NCBI Official Synonym Symbols

CD16; FCG3; CD16b; FCGR3; FCR-10; FCRIII; FCRIIIb

UniProt Protein Name

Low affinity immunoglobulin gamma Fc region receptor III-B

UniProt Synonym Protein Names

Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD_antigen: CD16b

Protein Family

Low affinity immunoglobulin gamma Fc region receptor

UniProt Gene Name

FCGR3B

UniProt Synonym Gene Names

CD16B; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb

UniProt Entry Name

FCG3B_HUMAN

NCBI Protein Information

low affinity immunoglobulin gamma Fc region receptor III-B

NCBI Summary for FCGR3B

The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

UniProt Comments for FCGR3B

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Research Articles on FCGR3B

1. A high copy number of FCGR3B is associated with psoriasis vulgaris in Han Chinese.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCGR3B active protein

Reference Product	PubMed Publications
FCGR3A active protein	>59 publications with FCGR3B and FCGR3A
SYK active protein	>6 publications with FCGR3B and SYK
APCS active protein	>4 publications with FCGR3B and APCS
CD28 active protein	>4 publications with FCGR3B and CD28
CD2 active protein	>4 publications with FCGR3B and CD2

Diseases associated with FCGR3B active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>81 publications with FCGR3B and Inflammation
Necrosis Antibodies	>64 publications with FCGR3B and Necrosis
Cardiovascular Diseases Antibodies	>63 publications with FCGR3B and Cardiovascular Diseases
Syndrome Antibodies	>35 publications with FCGR3B and Syndrome
Lung Diseases Antibodies	>27 publications with FCGR3B and Lung Diseases
Nervous System Diseases Antibodies	>18 publications with FCGR3B and Nervous System Diseases
Lupus Nephritis Antibodies	>17 publications with FCGR3B and Lupus Nephritis
Pain Antibodies	>8 publications with FCGR3B and Pain
Agranulocytosis Antibodies	>7 publications with FCGR3B and Agranulocytosis
Granulomatosis with Polyangiitis Antibodies	>7 publications with FCGR3B and Granulomatosis with Polyangiitis

Organs/Tissues associated with FCGR3B active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>388 publications with FCGR3B and Blood
Kidney Antibodies	>22 publications with FCGR3B and Kidney
Lung Antibodies	>17 publications with FCGR3B and Lung
Uterus Antibodies	>13 publications with FCGR3B and Uterus
Liver Antibodies	>8 publications with FCGR3B and Liver
Brain Antibodies	>8 publications with FCGR3B and Brain
Placenta Antibodies	>7 publications with FCGR3B and Placenta
Prostate Antibodies	>3 publications with FCGR3B and Prostate
Pancreas Antibodies	>2 publications with FCGR3B and Pancreas
Stomach Antibodies	>2 publications with FCGR3B and Stomach