Caspase-1 (CASP1) Active Protein

Name: CASP1 Active Protein; Caspase-1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844936
Price: 410 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844936

Background: Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa)… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Caspase-1 (Casp1), Active Protein

Full Product Name

Active Caspase-1, rat recombinant

Product Gene Name

Casp1 active protein

Product Synonym Names

Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; IL-1BC; p45.

Host

E Coli

Form/Format

Semi-Dry
Appearance: Semi-Dry

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

~ 34.6 KDa

3D Structure

ModBase 3D Structure for P43527

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute to 1 unit per mul in PBS containing 15% glycerol.

Biological Activity

The caspase-1 is routinely tested at MyBioSource for its ability to cleave these two substrates Ac-YVAD-pNA or Ac-YVAD-AFC (1103-200).

Results

>3000 units/mg

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for Casp1 active protein

Other Notes

Small volumes of Casp1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Casp1 purchase

MBS844936 is an active protein targeting Casp1. Also known as Active Caspase-1, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Casp1. It may not necessarily be applicable to this product.

NCBI GI #

1170463

NCBI Accession #

P43527.1

UniProt Primary Accession #

P43527

NCBI Official Full Name

Caspase-1

UniProt Protein Name

Caspase-1

UniProt Synonym Protein Names

Interleukin-1 beta convertase; IL-1BC

Protein Family

Caspase

UniProt Gene Name

Casp1

UniProt Synonym Gene Names

Il1bc; Il1bce; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme

UniProt Entry Name

CASP1_RAT

NCBI Summary for Casp1

apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 2006]

UniProt Comments for Casp1

CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity)

Protein type: EC 3.4.22.36; Apoptosis; Protease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.